Targeted Pituitary Adenylate Cyclase-Activating Peptide Therapies for Migraine

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Anne L H VollesenMessoud Ashina

Abstract

Here, we review the role of pituitary adenylate cyclase-activating peptide-38 (PACAP38) in migraine pathophysiology and data implicating PAC1 receptor as a future drug target in migraine. Much remains to be fully elucidated about migraine pathophysiology, but recent attention has focused on signaling molecule PACAP38, a vasodilator able to induce migraine attacks in patients who experience migraine without aura. PACAP38, with marked and sustained effect, dilates extracerebral arteries but not the middle cerebral artery. The selective affinity of PACAP38 to the PAC1 receptor makes this receptor a highly interesting and potential novel target for migraine treatment. Efficacy of antagonism of this receptor should be investigated in randomized clinical trials.

References

Apr 25, 1994·Neuroscience Letters·J D MikkelsenJ Fahrenkrug
Jan 19, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L OdumL B Ebskov
Jul 21, 1999·Journal of the Autonomic Nervous System·J TajtiL Edvinsson
Dec 29, 2000·Neurophysiologie clinique = Clinical neurophysiology·R PeyronL García-Larrea
Jun 8, 2001·Peptides·S GulbenkianL Edvinsson
Jun 26, 2001·Cephalalgia : an International Journal of Headache·J TajtiL Edvinsson
Apr 26, 2002·Cephalalgia : an International Journal of Headache·R UddmanL Edvinsson
Sep 13, 2002·Brain Research. Molecular Brain Research·Priya Chaudhary, Thomas K Baumann
May 26, 2005·Brain Research. Brain Research Reviews·Lars Edvinsson, Rolf Uddman
Feb 27, 2007·Regulatory Peptides·Steffen BirkJes Olesen
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Feb 8, 2008·Cephalalgia : an International Journal of Headache·A RahmannM Ashina
Feb 15, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melissa M J FarnhamPaul M Pilowsky
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Dec 5, 2008·Brain : a Journal of Neurology·Henrik Winther SchytzMessoud Ashina
Dec 27, 2008·Pharmacology & Therapeutics·Louise Dickson, Keith Finlayson
Feb 18, 2009·Cephalalgia : an International Journal of Headache·L J BoniS Gupta
Feb 23, 2010·Current Opinion in Neurology·Henrik W SchytzMessoud Ashina
Oct 27, 2010·Cephalalgia : an International Journal of Headache·Kayi Y ChanSaurabh Gupta
Sep 15, 2011·European Journal of Pharmacology·Michael BaunInger Jansen-Olesen
Dec 17, 2011·Cephalalgia : an International Journal of Headache·Faisal Mohammad AminMessoud Ashina
Mar 17, 2012·Cephalalgia : an International Journal of Headache·Michael BaunInger Jansen-Olesen
May 15, 2012·Neuroscience Letters·Melissa A FarmerA Vania Apkarian

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Citations

May 10, 2018·The Journal of Headache and Pain·Messoud Ashina, Paolo Martelletti
Jul 14, 2019·Cephalalgia : an International Journal of Headache·Hashmat GhanizadaMessoud Ashina
Jul 11, 2019·Headache·Zachariah Bertels, Amynah Amir Ali Pradhan
Jun 4, 2020·Cephalalgia : an International Journal of Headache·Jacob Carl Alexander EdvinssonKristian Agmund Haanes
Nov 19, 2018·Nature Reviews. Neurology·Nazia Karsan, Peter J Goadsby
Oct 28, 2019·Molecular & Cellular Proteomics : MCP·Krishna D. B. AnapindiAmynah A Pradhan
Apr 19, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Peter J Goadsby, Philip R Holland
Jun 28, 2019·Frontiers in Neurology·Zhiye ChenShengyuan Yu
Dec 1, 2019·Molecular & Cellular Proteomics : MCP·D B Anapindi KrishnaAmynah A Pradhan
May 30, 2020·Neuropharmacology·Elizabeth C Delery, Scott Edwards
May 19, 2021·Neurology India·Brian M YanStephanie J Nahas

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Methods Mentioned

BETA
imaging techniques

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