Targeted Sequencing Analysis of the Leptin Receptor Gene Identifies Variants Associated with Obstructive Sleep Apnoea in Chinese Han Population

Lung
Juan LiYongxiang Wei

Abstract

Obstructive sleep apnea (OSA) is a common sleep disorder that is influenced by various environmental and genetic factors. The potential associations of leptin and leptin receptor (LEPR) polymorphisms with OSA have been studied in different populations; however, the results remain inconclusive. The aim of this study was to examine the association between LEPR gene polymorphisms and OSA risk. A total of 322 samples were used, including 226 OSA subjects and 96 controls. Targeted sequencing of the entire LEPR gene was performed in all subjects. Polysomnography was used to diagnose obstructive sleep apnea. The associations between variants and OSA were determined by multivariate regression analyses. Four single-nucleotide polymorphisms of LEPR were identified in all subjects. The genotype frequency of locus rs3790435 was significantly different between the OSA and control groups. Specifically, the variant genotype rs3790435 CC in LEPR was associated with a lower risk of OSA (OR 0.462, 95% CI 0.250-0.854, p = 0.014) in a recessive model after controlling for potential confounders. After BMI stratification, obese patients with this variant genotype were found to have a lower risk of developing OSA. Moreover, subjects with the rs379043...Continue Reading

References

Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·H NakanoG A Farkas
Jan 18, 2003·Sleep Medicine Reviews·Susan Redline, Peter V. Tishler
Feb 8, 2005·The Journal of Physiology·Robert B FogelRobert J Pierce
Aug 10, 2005·Respiration; International Review of Thoracic Diseases·Tansu Ulukavak CiftciAyse Bilgihan
Nov 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aaron D LaposkyFred W Turek
Feb 15, 2008·Diabetes Care·Giora Pillar, Naim Shehadeh
Oct 10, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A D LaposkyF W Turek
Jul 17, 2010·Neuroscience and Behavioral Physiology·E M InyushkinaA N Inyushkin
Oct 14, 2010·Seminars in Respiratory and Critical Care Medicine·Bradley A EdwardsAtul Malhotra
Feb 22, 2012·Journal of Applied Physiology·Mikhael PolotskyAlan R Schwartz
Oct 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Richard B BerryUNKNOWN American Academy of Sleep Medicine
Oct 20, 2012·Sleep Medicine Reviews·Henri TuomilehtoMatti Uusitupa
Apr 17, 2013·American Journal of Epidemiology·Paul E PeppardKhin Mae Hla
Jun 1, 2013·American Journal of Respiratory and Critical Care Medicine·Danny J EckertAndrew Wellman
Aug 6, 2013·Lancet·Amy S JordanAtul Malhotra
Aug 21, 2013·Journal of Molecular Neuroscience : MN·Yuping WangWeihong Pan
Aug 31, 2013·JAMA : the Journal of the American Medical Association·Kathryn A MyersDavid L Simel
Oct 2, 2013·Sleep Medicine Reviews·Weihong Pan, Abba J Kastin
Aug 27, 2014·Metabolism: Clinical and Experimental·Gilberto Paz-FilhoJulio Licinio
Feb 11, 2015·Sleep & Breathing = Schlaf & Atmung·Sophia E SchizaIzolde Bouloukaki
Mar 16, 2016·American Journal of Respiratory and Critical Care Medicine·Brian E CadeSusan Redline
Feb 7, 2017·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Vishesh K KapurChristopher G Harrod
Nov 8, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sutapa MukherjeeLyle J Palmer
Dec 2, 2017·Journal of Sleep Research·Bjørn BjorvatnStåle Pallesen

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Citations

Jun 9, 2021·Annual Review of Nutrition·Hassan S Dashti, José M Ordovás
Nov 16, 2021·Acta Medica (Hradec Králové)·Aleksandr Abaturov, Anna Nikulina

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
PCR
Chip

Software Mentioned

EmpowerStats
Ion Ampliseq® Designer
R

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