Targeted serum metabolite profiling and sequential metabolite ratio analysis for colorectal cancer progression monitoring

Analytical and Bioanalytical Chemistry
Jiangjiang ZhuDaniel Raftery

Abstract

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and a major cause of human morbidity and mortality. In addition to early detection, close monitoring of disease progression in CRC can be critical for patient prognosis and treatment decisions. Efforts have been made to develop new methods for improved early detection and patient monitoring; however, research focused on CRC surveillance for treatment response and disease recurrence using metabolomics has yet to be reported. In this proof of concept study, we applied a targeted liquid chromatography tandem mass spectrometry (LC-MS/MS) metabolic profiling approach focused on sequential metabolite ratio analysis of serial serum samples to monitor disease progression from 20 CRC patients. The use of serial samples reduces patient to patient metabolic variability. A partial least squares-discriminant analysis (PLS-DA) model using a panel of five metabolites (succinate, N2, N2-dimethylguanosine, adenine, citraconic acid, and 1-methylguanosine) was established, and excellent model performance (sensitivity = 0.83, specificity = 0.94, area under the receiver operator characteristic curve (AUROC) = 0.91 was obtained, which is superior to the traditional CRC monitoring...Continue Reading

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Citations

Jun 2, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jieying GaoMin Ding
Jun 19, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Katie SchelliJiangjiang Zhu
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Mar 10, 2018·International Journal of Molecular Sciences·Tetsushi NakajimaMasahiro Sugimoto
Dec 19, 2018·International Journal of Cancer. Journal International Du Cancer·Inna ZaimenkoJan Lisec
May 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cuizhu WangFang Wang
May 28, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·David K ScovilleJulia Yue Cui
Jun 18, 2020·British Journal of Biomedical Science·R RashedF Zahran
Nov 14, 2019·Asia Pacific Allergy·Domingo BarberMaria M Escribese
Jul 11, 2019·Molecular and Clinical Oncology·Nurul Azmir Amir HashimMusalmah Mazlan
Feb 20, 2021·Scientific Reports·Kazuki YokotaAkinari Hinoki
May 1, 2021·Cancers·Ana Carolina B Sant'Anna-SilvaHelmut Klocker
Jun 28, 2019·Journal of Proteome Research·Paniz JasbiHaiwei Gu
Apr 26, 2019·New Biotechnology·Veronica GhiniPaola Turano

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