Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.

International Journal of Molecular Sciences
Montserrat Colilla, Maria Vallet-Regi

Abstract

The rise of antibiotic resistance and the growing number of biofilm-related infections make bacterial infections a serious threat for global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infection-targeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the...Continue Reading

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Citations

Jan 14, 2021·Nanomaterials·John Jairo Aguilera-CorreaMaría Vallet-Regí
Feb 13, 2021·Chemistry : a European Journal·Viktoriya Sokolova, Matthias Epple
Jul 9, 2021·International Journal of Nanomedicine·Rafael R Castillo, María Vallet-Regí
Aug 12, 2021·Materials Today. Bio·M Vallet-Regi, A J Salinas

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Methods Mentioned

BETA
amidation
X-ray

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