Targeted Therapies and Biomarkers in Small Cell Lung Cancer.

Frontiers in Oncology
Hirokazu TaniguchiCharles M Rudin

Abstract

Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid growth, early metastasis, and acquired therapeutic resistance. A majority of patients with SCLC have extensive-stage (ES) disease, defined as the presence of metastatic disease outside the hemithorax at first diagnosis. SCLC has been considered "a graveyard for drug development," with chemotherapy remaining the standard treatment for first- and second-line management until quite recently. In contrast to NSCLC, identifying therapeutic targets in SCLC has been challenging, partly because driver mutations are primarily loss of function, involving the tumor suppressor genes RB1 and TP53 or currently untargetable (e.g., amplification of MYC family members). Recent gene expression profiling of SCLC cells lines, patient samples and representative murine models, have led to a proposed delineation of four major subtypes for SCLC distinguished by differential expression of four key transcriptional regulators (ASCL1, NEUROD1, POU2F3, and YAP1). Our understanding of the biology of SCLC has indeed significantly improved recently due to the continued efforts of the dedicated investigators in this field, but the therapeutic options remain dismal. While recent res...Continue Reading

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Citations

Jan 30, 2021·Frontiers in Cell and Developmental Biology·Fei MoXuelei Ma
Dec 8, 2020·Frontiers in Oncology·Sonam PuriJhanelle E Gray
Mar 16, 2021·Molecular Therapy Oncolytics·Anna SchwendenweinBalazs Dome
Oct 5, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marina K BaineNatasha Rekhtman
May 1, 2021·Cancers·Antonella De LucaNicola Normanno
Jun 3, 2021·International Journal of Molecular Sciences·Ani-Simona SevastreAnica Dricu
Jul 9, 2021·Cancer Causes & Control : CCC·Laurie GrieshoberJennifer A Doherty
Aug 6, 2021·Science Translational Medicine·Triparna Sen
Aug 11, 2021·Expert Review of Respiratory Medicine·Andrea BiancoDanilo Rocco
Aug 28, 2021·Cells·Miriam Sánchez-OrtegaAntonio Garrido
Nov 9, 2021·Journal of Cancer Research and Clinical Oncology·Xuetian GaoJisheng Li

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Methods Mentioned

BETA
xenografts
xenograft

Clinical Trials Mentioned

NCT03879798
NCT03319940

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