Targeted therapies as adjuvant treatment for early-stage colorectal cancer: first impressions and clinical questions

Clinical Colorectal Cancer
Susana Banerjee, David Cunningham

Abstract

Survival rates for metastatic colorectal cancer (CRC) have increased considerably over the years largely because of the application of optimized chemotherapy regimens. More recently, the addition of the targeted agents bevacizumab, cetuximab, and panitumumab in advanced disease has also demonstrated clinical benefit. Adjuvant chemotherapy is the standard of care in patients with early-stage CRC who are at high risk of recurrence. One challenge is how to apply targeted agents in early-stage CRC. Initial results from the NSABP-08 trial in CRC, the first report of bevacizumab in the adjuvant treatment of solid cancers, are disappointing. Nevertheless, the results of several important phase III trials of targeted adjuvant therapy are awaited. Until then, the use of targeted agents in early-stage CRC cannot be recommended. The identification of biomarkers to select patients who might derive clinical benefit is crucial in determining the full potential of targeted agents in the adjuvant setting. In this review, we discuss the biologic rationale for targeted therapies in early-stage CRC, the current clinical trials, and the clinical challenges facing the success of these agents in the adjuvant setting.

References

Feb 8, 1990·The New England Journal of Medicine·C G MoertelJ H Glick
Dec 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C G MoertelJ H Glick
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J O'ConnellH S Wieand
May 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G RiethmüllerR Pichlmayr
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B MeisterR Möhle
Apr 20, 2001·The New England Journal of Medicine·T WatanabeS R Hamilton
Oct 3, 2002·Nature Reviews. Cancer·Robert Kerbel, Judah Folkman
Jun 5, 2003·Nature Reviews. Cancer·Gabriele Bergers, Laura E Benjamin
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thierry AndreAimery de Gramont
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Oct 7, 2004·Journal of the National Cancer Institute·Jessica B O'ConnellClifford Y Ko
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PopatR S Houlston
May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fairooz F KabbinavarSomnath Sarkar
Jul 1, 2005·The New England Journal of Medicine·Chris TwelvesWerner Scheithauer
Oct 21, 2005·The New England Journal of Medicine·Martine J Piccart-GebhartUNKNOWN Herceptin Adjuvant (HERA) Trial Study Team
Nov 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J SargentAimery De Gramont
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel G HallerRobert J Mayer
Mar 10, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I Chau, D Cunningham
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alain BarrierSandrine Dudoit
Oct 4, 2006·The Journal of Clinical Investigation·Michael R MancusoDonald M McDonald
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Philip KueblerNorman Wolmark
Aug 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard B SaltzRobert J Mayer
Sep 22, 2007·European Journal of Clinical Investigation·A GiatromanolakiK C Gatter
Sep 27, 2007·British Journal of Cancer·W SchippingerUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Nov 16, 2007·The New England Journal of Medicine·Derek J JonkerMalcolm J Moore
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Axel Grothey
Dec 18, 2007·Lancet·David Cunningham, Naureen Starling
Dec 18, 2007·Lancet·UNKNOWN Quasar Collaborative GroupDavid J Kerr
Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles S FuchsJosé Barrueco
Apr 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alberto F SobreroHoward A Burris
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Randolph HechtRafael G Amado
Jan 31, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M YchouA Kramar
Mar 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony L A FieldsPaul Wissel
Mar 24, 2009·Lancet·Ronald P DematteoUNKNOWN American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team
Mar 24, 2009·Nature Medicine·Andrew R ReynoldsKairbaan M Hodivala-Dilke
Apr 3, 2009·The New England Journal of Medicine·Eric Van CutsemPhilippe Rougier
May 6, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carmen J AllegraNorman Wolmark

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Citations

Jul 31, 2019·Scientific Reports·Sebastian SchölchNuh N Rahbari

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