Targeted Therapies for Autoimmune Bullous Diseases: Current Status

Drugs
Kyle T AmberMichael Hertl

Abstract

Autoimmune bullous skin disorders are rare but meaningful chronic inflammatory diseases, many of which had a poor or devastating prognosis prior to the advent of immunosuppressive drugs such as systemic corticosteroids, which down-regulate the immune pathogenesis in these disorders. Glucocorticoids and adjuvant immunosuppressive drugs have been of major benefit for the fast control of most of these disorders, but their long-term use is limited by major side effects such as blood cytopenia, osteoporosis, diabetes mellitus, hypertension, and gastrointestinal ulcers. In recent years, major efforts were made to identify key elements in the pathogenesis of autoimmune bullous disorders, leading to the identification of their autoantigens, which are mainly located in desmosomes (pemphigus) and the basement membrane zone (pemphigoids). In the majority of cases, immunoglobulin G, and to a lesser extent, immunoglobulin A autoantibodies directed against distinct cutaneous adhesion molecules are directly responsible for the loss of cell-cell and cell-basement membrane adhesion, which is clinically related to the formation of blisters and/or erosions of the skin and mucous membranes. We describe and discuss novel therapeutic strategies that...Continue Reading

References

Nov 1, 1991·The Journal of Allergy and Clinical Immunology·D L Hamilos, J Christensen
Apr 1, 1970·The Journal of Clinical Investigation·A MorellT A Waldmann
Nov 1, 1994·Clinical Immunology and Immunopathology·D AmranE W Gelfand
May 1, 1995·The Journal of Dermatology·N MaekawaY Asada
Mar 1, 1995·International Journal of Dermatology·M CaproniP Fabbri
Jan 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Y PanL M Amzel
Feb 1, 1995·The Journal of Clinical Investigation·M DaëronW H Fridman
Apr 1, 1994·Journal of Dermatological Science·F FurukawaS Imamura
Feb 1, 1994·Clinical Immunology and Immunopathology·N RondaM D Kazatchkine
Aug 1, 1993·Scandinavian Journal of Immunology·V HurezM D Kazatchkine
Apr 1, 1993·The British Journal of Dermatology·H SohY Asada
Mar 1, 1996·European Journal of Immunology·V GhetieE S Ward
Dec 1, 1995·Current Opinion in Immunology·A CoutinhoS Avrameas
May 1, 1997·Journal of Dermatological Science·Y Kawachi, F Otsuka
Jun 30, 1998·Archives of Dermatology·H SchoenB Volc-Platzer
Oct 13, 1998·The Journal of Allergy and Clinical Immunology·K SigmanB Mazer
Mar 9, 1999·The Journal of Allergy and Clinical Immunology·J D SpahnE W Gelfand
May 4, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·N InoM Odaka
Oct 12, 2000·Acta Dermato-venereologica·M ShrikhandeN Yawalkar
Jan 10, 2001·Journal of the American Academy of Dermatology·L Engineer, A R Ahmed
Mar 17, 2001·Scandinavian Journal of Immunology·E Alvarado-FloresR Herrera-Esparza
Jul 24, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·K C BholA R Ahmed
Aug 10, 2001·The Journal of Allergy and Clinical Immunology·Q Zhuang, B Mazer
Jan 10, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Naveed SamiA Razzaque Ahmed
Jun 19, 2002·The Journal of Experimental Medicine·Alexis M Kalergis, Jeffrey V Ravetch
Dec 17, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Naveed SamiA Razzaque Ahmed
Feb 27, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mieko ToyodaStanley C Jordan

❮ Previous
Next ❯

Citations

Apr 2, 2019·The British Journal of Dermatology·C Sitaru
Jul 18, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·K KridinK T Amber
Nov 20, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·F SolimaniK Ghoreschi
Sep 9, 2019·The British Journal of Dermatology·R Maglie, M Hertl
Mar 16, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Göbel, R Eming
Dec 19, 2019·Frontiers in Immunology·Farzan SolimaniKamran Ghoreschi
Oct 12, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·R Maglie, M Hertl
Oct 1, 2019·Expert Review of Clinical Immunology·Rebecca L YanovskyA Razzaque Ahmed
Dec 16, 2019·American Journal of Clinical Dermatology·James E Frampton
Aug 30, 2020·American Journal of Clinical Dermatology·Emily M Altman
May 28, 2019·Frontiers in Immunology·Kentaro IzumiRalf J Ludwig
Jul 12, 2019·Frontiers in Immunology·Dario DidonaMichael Hertl
Oct 9, 2020·Dermatologic Therapy·Luca Giannetti, Alberto Murri Dello Diago
Sep 10, 2019·Lancet·Enno SchmidtPascal Joly
Nov 17, 2020·Frontiers in Immunology·Katharina MeierKamran Ghoreschi
Mar 2, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·D Didona, M Hertl
Apr 20, 2021·Oxidative Medicine and Cellular Longevity·P SliwiakC Hudemann
May 6, 2021·Journal of Oral Biology and Craniofacial Research·Shankargouda PatilShailesh Gondivkar
Mar 9, 2021·Journal of the American Academy of Dermatology·Carmen M MontagnonStanislav N Tolkachjov
Jun 17, 2020·The Journal of Dermatological Treatment·Pedro Miguel GarridoPaulo Filipe
Jul 11, 2021·Indian Journal of Dermatology, Venereology and Leprology·Anuradha BishnoiRahul Mahajan
Jun 26, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·F SolimaniK Meier
Aug 27, 2021·Frontiers in Medicine·Thomas Schmitt, Jens Waschke
Jun 17, 2020·Panminerva Medica·Virginia A JonesKyle T Amber
Nov 24, 2020·The Journal of Investigative Dermatology·Roberto MaglieMichael Hertl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bullous Pemphigoid

Bullous pemphigoid is a rare immune system disorder and skin condition that causes large, fluid-filled blisters. Bullous pemphigoid commonly affects older adults and appears in areas such as the lower abdomen, upper thighs or armpits. Discover the latest research on bullous pemphigoid here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Therapeutische Umschau. Revue thérapeutique
Michael HertlLuca Borradori
Atherosclerosis. Supplements
Alexander Mlynek, Michael Meurer
Current Problems in Dermatology
Caroline Corbaux, P Joly
© 2022 Meta ULC. All rights reserved