Targeted therapies in lung cancer

Current Pharmaceutical Design
Robert Pirker, Martin Filipits

Abstract

Targeted therapies have improved and will continue to improve the outcome of lung cancer. Current strategies focus on the blockade of growth factor receptors and the inhibition of angiogenesis. Epidermal growth factor receptor (EGFR)-directed tyrosine kinase inhibitors (TKIs) have already been established as a treatment option in patients with advanced non-small cell lung cancer (NSCLC) progressing after prior treatment with chemotherapy. EGFR-directed monoclonal antibodies in combination with platinum-based first-line chemotherapy have shown promising efficacy in phase II trials. In a phase III trial, cetuximab combined with cisplatin/vinorelbine resulted in superior survival compared to chemotherapy alone in patients with advanced EGFR-positive NSCLC. Inhibition of angiogenesis has also been successfully applied as a new treatment strategy. Bevacizumab added to palliative chemotherapy has improved progression-free survival in two phase III trials and overall survival in one of these trials in selected patients with advanced non-squamous cell lung cancer. Bevacizumab is now approved for selected patients with advanced NSCLC in combination with platinum-based chemotherapy. Other targeted therapies including dual and multi-kinas...Continue Reading

Citations

Jan 10, 2013·Targeted Oncology·Robert Pirker
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Hsin Hsien YehJuri G Gelovani
Dec 19, 2009·American Journal of Therapeutics·Jose Luis UllaEnrique Vazquez-Astray
Mar 5, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Stephen G SpiroRobert Pirker
Nov 27, 2010·Critical Reviews in Oncology/hematology·Robert Pirker, Martin Filipits
Sep 3, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Martin Filipits, Robert Pirker
Sep 27, 2013·British Journal of Nursing : BJN·Michael Evans
Nov 3, 2012·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Yoo Na KimChin A Yi
Jan 11, 2014·Current Opinion in Oncology·Robert Pirker
Dec 24, 2019·Cancer Control : Journal of the Moffitt Cancer Center·Fabio CofanoDiego Garbossa
Aug 24, 2017·Journal of Thoracic Imaging·Girish S ShroffMylene T Truong
Jul 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katharina SchmidMartin Filipits

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