Targeted therapies in renal cell cancer: recent developments in imaging.

Targeted Oncology
Astrid A M van der VeldtEpie Boven

Abstract

Targeted therapy has significantly improved the perspectives of patients with metastatic renal cell cancer (mRCC). Frequently, these new molecules cause disease stabilization rather than substantial tumor regression. As treatment options expand with the growing number of targeted agents, there is an increasing need for surrogate markers to early assess tumor response. Here, we review the currently available imaging techniques and response evaluation criteria for the assessment of tumor response in mRCC patients. For computed tomography (CT), different criteria are discussed including the Response Evaluation Criteria in Solid Tumors (RECIST), the Choi criteria, the modified Choi criteria, and the size and attenuation CT (SACT) criteria. Functional imaging modalities are discussed, such as dynamic contrast-enhanced CT (DCE-CT), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), dynamic contrast-enhanced ultrasonography (DCE-US), and positron emission tomography (PET).

References

Jul 1, 1997·Current Problems in Cancer·R J MotzerW J Berg
Nov 11, 1998·Nature Medicine·A F ShieldsT J Mangner
Mar 17, 2000·Journal of Neuro-oncology·P D SchellingerA Thron
Oct 26, 2000·Academic Radiology·K A MilesT Y Lee
Nov 18, 2000·Clinical Nuclear Medicine·M CharronD W Townsend
Oct 5, 2001·Lancet·G H MickischUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC) Genitourinary Group
Oct 5, 2001·The Journal of Urology·A J PantuckA S Belldegrun
Nov 14, 2001·Lancet·A T van OosteromUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Apr 26, 2002·International Journal of Urology : Official Journal of the Japanese Urological Association·Hideshi MiyakitaSeiei Yasuda
Jul 31, 2002·Lancet·Andrzej Dzik-JuraszSimon Doran
Sep 5, 2002·Nature Reviews. Cancer·Sanjiv Sam Gambhir
Sep 14, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstJames L Abbruzzese
Sep 21, 2002·Molecular and Cellular Biology·Christine C HudsonRobert T Abraham
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yael MardorThomas Tichler
Jun 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Helen L AndersonPatricia M Price
Jun 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan M GalbraithGordon J S Rustin
Jul 8, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Nicolas AideDenis Agostini
Sep 6, 2003·Cancer Cell·James B BrugarolasWilliam G Kaelin
Sep 6, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S StroobantsA van Oosterom
Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Navneet S MajhailRonald M Bukowski
Feb 10, 2004·The Journal of Urology·Robert C FlaniganE David Crawford
May 29, 2004·Investigative Radiology·Valérie RouffiacAlain Roche
Oct 16, 2004·The British Journal of Radiology·M CovaR Pozzi-Mucelli
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Apr 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bradford A MoffatBrian D Ross
May 26, 2005·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Neslihan KabakciZiya Kirkali
Jul 16, 2005·Bioorganic & Medicinal Chemistry Letters·Ji-Quan WangQi-Huang Zheng
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Domenic A Sica
Mar 29, 2006·Journal of Vascular and Interventional Radiology : JVIR·Ihab R KamelJean-Francois H Geschwind
Apr 25, 2006·AJR. American Journal of Roentgenology·Jin Hong WangXin Qing Mao

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Citations

Jun 13, 2012·Cancer Metastasis Reviews·Joan CarlesFrancisco Xavier García del Muro
May 17, 2011·Future Oncology·Asim Afaq, Oguz Akin
Oct 1, 2013·Abdominal Imaging·Dhakshinamoorthy GaneshanVikas Kundra
Jul 2, 2014·La Radiologia medica·Anna Maria IerardiGianpaolo Carrafiello
May 21, 2014·Journal of Cancer Research and Clinical Oncology·Taekmin KwonJun Hyuk Hong
Oct 11, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Blanca Paño BrufauCarlos Nicolau Molina
Aug 28, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Karen Cristina Barbosa ChavesMaria Helena Bellini
Jul 19, 2011·Hematology/oncology Clinics of North America·Katherine M KrajewskiIvan Pedrosa
Nov 21, 2014·BJU International·Sebastian MafeldPhilip Haslam
Nov 29, 2015·Magnetic Resonance Imaging Clinics of North America·Alberto Diaz de LeonIvan Pedrosa
Sep 21, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A M MolinaR J Motzer
May 20, 2016·Abdominal Radiology·Reza SirousAndrew D Smith
Dec 15, 2010·Urologia Internationalis·Emilio SaccoPierfrancesco Bassi
Feb 6, 2016·Experimental Biology and Medicine·Yangyang XuWanhai Xu
Dec 21, 2012·AJR. American Journal of Roentgenology·Roberto García-FigueirasAntonio Gómez-Caamaño

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Methods Mentioned

BETA
imaging techniques
X-ray
imaging technique

Software Mentioned

CT perfusion
RECIST

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