Targeted therapy in esophageal cancer

Expert Review of Gastroenterology & Hepatology
Lei ZhangDaiming Fan

Abstract

An increasing number of patients are diagnosed with esophageal cancer at an advanced stages, and only a small group of them can benefit from the traditional chemotherapy and radiotherapy. So far, multiple monoclonal antibodies and tyrosine kinase inhibitors have been developed, alone or in combination with traditional therapy, to improve the prognosis of patients with advanced esophageal cancer. This review summarizes the recent advances of targeted therapies against EGFR, HER2, VEGFR and c-MET in esophageal cancer. More clinical trials should be performed to evaluate the efficacy and safety of various targeted therapy regimens. Future basic research should focus on investigating the molecular mechanisms of therapeutic targets in esophageal cancer.

References

Apr 12, 2002·The New England Journal of Medicine·John D BirkmeyerDavid E Wennberg
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemUNKNOWN V325 Study Group
Nov 30, 2006·Neoplasia : an International Journal for Oncology Research·Gregory A WatsonSteven J Hughes
Jan 12, 2007·The New England Journal of Medicine·Bernard EscudierUNKNOWN TARGET Study Group
Jan 25, 2007·Annals of Surgery·Bernard M SmithersJanine M Thomas
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jaffer A AjaniUNKNOWN V-325 Study Group
Jun 25, 2008·Annual Review of Biophysics·Kathryn M Ferguson
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Jan 27, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cora N SternbergRobert E Hawkins
Feb 9, 2010·Cell Adhesion & Migration·Ryan E Lawrence, Ravi Salgia
Mar 31, 2010·International Journal of Radiation Oncology, Biology, Physics·Gang LiShixiu Wu
Oct 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Axel Grothey
Dec 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manish A ShahDavid P Kelsen
Dec 1, 2011·Therapeutic Advances in Medical Oncology·J Rafael Sierra, Ming-Sound Tsao
Jan 20, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·M J D PrinsR van Hillegersberg
Mar 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jordan M SchmittNasser Hanna
Mar 31, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X F GuoB G Deng
Aug 7, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y ZhaiL Wang
Sep 18, 2012·Current Topics in Medicinal Chemistry·Emmanuelle NorguetJean-Francois Seitz
Oct 31, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A F C OkinesD Cunningham
Dec 5, 2012·BMC Cancer·Isabela Martins GonzagaLuis Felipe Ribeiro Pinto
Jan 22, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J D PrinsF J W Ten Kate
Feb 5, 2013·Lancet·Arjun PennathurJames D Luketich
Feb 16, 2013·British Journal of Cancer·N C TebbuttUNKNOWN Australasian Gastro-Intestinal Trials Group (AGITG)
Feb 22, 2013·International Journal of Oncology·Hiroaki KatoKazuto Nishio
Mar 14, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A F C OkinesA Wotherspoon
Jun 12, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Donald RichardsLina Asmar
Sep 14, 2013·Science·Mark X Sliwkowski, Ira Mellman
Sep 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jian-Cheng LiJian-Ji Pan

❮ Previous
Next ❯

Citations

Sep 14, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yinan MaMinghua Bai
Jan 23, 2018·Omics : a Journal of Integrative Biology·Kevin DzoboM Iqbal Parker
Mar 4, 2020·International Journal of Molecular Sciences·Caterina VivaldiLorenzo Fornaro
Sep 11, 2020·Computational and Mathematical Methods in Medicine·Yunhao SunHaitao Ma
Aug 10, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Chunhong RenXin Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.