Targeted therapy in gliomas

Current Oncology Reports
Mohamed Ali Hamza, Mark R Gilbert

Abstract

The survival outcome of patients with malignant gliomas is still poor, despite advances in surgical techniques, radiation therapy and the development of novel chemotherapeutic agents. The heterogeneity of molecular alterations in signaling pathways involved in the pathogenesis of these tumors contributes significantly to their resistance to treatment. Several molecular targets for therapy have been discovered over the last several years. Therapeutic agents targeting these signaling pathways may provide more effective treatments and may improve survival. This review summarizes the important molecular therapeutic targets and the outcome of published clinical trials involving targeted therapeutic agents in glioma patients.

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·Luther W BradyP Black
May 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M YoshidaT Beppu
Jul 1, 1993·Brain Pathology·P KleihuesBernd W Scheithauer
Apr 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G StragliottoJ Y Delattre
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard A FineW K Alfred Yung
Aug 3, 2000·Journal of the National Cancer Institute·P A MarksR A Rifkind
Oct 21, 2000·Journal of Neurology·J C ReijneveldMartin J B Taphoorn
Jan 5, 2001·Experimental Cell Research·S G Gray, T J Ekström
Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·Fred G BarkerK Aldape
Jan 5, 2002·Journal of Neuro-oncology·G M MarxH R Wheeler
Jan 5, 2002·Journal of Cancer Research and Clinical Oncology·M Assimakopoulou, J Varakis
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Morris D GrovesVictor A Levin
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard A FineCraig B Borkowf
Nov 26, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeremy N RichHenry S Friedman
Apr 10, 2004·Journal of Neuro-oncology·Fabian BaumannRené L Bernays
May 4, 2004·Nature Reviews. Cancer·Julian Adams
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arnab ChakravartiJay S Loeffler
Sep 24, 2004·International Journal of Radiation Oncology, Biology, Physics·Susan M ChangMichael D Prados
Nov 2, 2004·Acta Neuropathologica·Christiane B KnobbeGuido Reifenberger
Nov 10, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian I Rini, Eric J Small
Mar 11, 2005·The New England Journal of Medicine·Roger StuppNational Cancer Institute of Canada Clinical Trials Group
Jun 16, 2005·Journal of the National Cancer Institute·Daphne A Haas-KoganDavid Stokoe
Jul 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Evanthia GalanisNorth Central Cancer Treatment Group
Jul 14, 2005·Investigational New Drugs·Susan M ChangNorth American Brain Tumor Consortium and the National Cancer Institute
Aug 2, 2005·Neuro-oncology·Michael W Graner, Darell D Bigner
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David A ReardonHenry S Friedman
Dec 27, 2005·Gene·Nicola NormannoDavid S Salomon
Feb 9, 2006·Current Oncology Reports·Santosh KesariPatrick Y Wen
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David A ReardonJeremy N Rich
Mar 22, 2006·Molecular Carcinogenesis·Daniel R PremkumarIan F Pollack
Apr 22, 2006·International Journal of Radiation Oncology, Biology, Physics·Sunil KrishnanNorth Central Cancer Treatment Group
May 26, 2006·Nature·Reuben J Shaw, Lewis C Cantley
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher E PelloskiKenneth Aldape
Aug 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy F CloughesyMichael D Prados
Aug 18, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrick Y WenMichael D Prados
Jan 25, 2007·Journal of Neuro-oncology·Annick DesjardinsDavid A Reardon
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger Stupp, Curzio Ruegg
May 24, 2007·Cancer·Sith SathornsumeteeJeremy N Rich
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher E PelloskiKenneth Aldape
Jun 16, 2007·International Journal of Radiation Oncology, Biology, Physics·Elizabeth Cohen-Jonathan MoyalChristine Toulas
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James J VredenburghHenry S Friedman
Oct 24, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Giovanna M D'Abaco, Andrew H Kaye
Dec 7, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Howard A FineCheryl Royce
Mar 11, 2008·Cancer Cell·Susanne KleberAna Martin-Villalba
May 15, 2008·Neuro-oncology·Surasak PhuphanichNew Approaches to Brain Tumor Therapy (NABTT) CNS Consortium
Jun 3, 2008·International Journal of Radiation Oncology, Biology, Physics·Jan DrappatzPatrick Y Wen
Jun 27, 2008·Journal of Neuro-oncology·John de GrootW K Alfred Yung
Jul 29, 2008·Journal of Neuro-oncology·Camilo E FadulJ Marc Pipas
Aug 30, 2008·Neuro-oncology·Robert LustigNew Approaches to Brain Tumor Therapy CNS Consortium
Aug 30, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Clovis Orlando da FonsecaThereza Quirico-Santos
Sep 19, 2008·Growth Factors·Antony W Burgess
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Luca Toschi, Pasi A Jänne
Oct 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul D BrownNorth Central Cancer Treatment Group Study N0177
Nov 1, 2008·Cancer·Doo-Sik KongDo-Hyun Nam
Nov 5, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David A ReardonLouis Nabors
Nov 20, 2008·Journal of Neuro-oncology·Teri N KreislLauren Abrey
Dec 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael D PradosDaphne A Haas-Kogan
Dec 17, 2008·International Journal of Radiation Oncology, Biology, Physics·Gregory J KubicekAdam P Dicker
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Teri N KreislHoward A Fine
Mar 25, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Evanthia GalanisJan Buckner
Jun 30, 2009·Journal of Neuro-oncology·David A ReardonHenry S Friedman
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stuart A GrossmanHoward A Fine
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry S FriedmanTimothy F Cloughesy
Oct 1, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Evangelia RazisGeorge Fountzilas
Nov 12, 2009·British Journal of Cancer·David A ReardonZariana Nikolova
Dec 1, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alba A BrandesMartin J van den Bent
Feb 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfgang WickHoward A Fine
Feb 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Jan DrappatzPatrick Y Wen
Feb 13, 2010·Neuro-oncology·Teri N KreislHoward A Fine
Mar 10, 2010·Journal of Neuro-oncology·Surasak PhuphanichJeffrey J Olson
Apr 23, 2010·Cancer Treatment Reviews·C PowellK J Harrington
May 5, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger StuppMichael Weller
May 12, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tracy T BatchelorRakesh K Jain
Jun 1, 2010·International Journal of Radiation Oncology, Biology, Physics·Joon H UhmKurt Jaeckle
Jul 10, 2010·Neuro-oncology·W K Alfred YungMichael D Prados
Aug 19, 2010·Neuro-oncology·Sith SathornsumeteeDavid A Reardon
Oct 6, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jann N SarkariaJan Buckner
Oct 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John H SampsonDarell D Bigner
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Phioanh Leia NghiemphuNorth American Brain Tumor Consortium
Dec 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Albert LaiTimothy F Cloughesy
May 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James J VredenburghHenry S Friedman
May 25, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John de GrootPatrick Y Wen
Jul 12, 2011·Journal of Neuro-oncology·David A ReardonHenry S Friedman
Jul 28, 2011·Cancer·Annick DesjardinsJames J Vredenburgh
Oct 12, 2011·Journal of Neuro-oncology·David A ReardonHenry S Friedman
Nov 1, 2011·Journal of Neurosurgery·Ashwatha NarayanaMichael L Gruber
Apr 5, 2012·European Journal of Histochemistry : EJH·A GaliaM Salemi
Apr 21, 2012·Cancer·Louis NaborsNew Approaches to Brain Tumor Therapy (NABTT) Central Nervous System Consortium
Jul 27, 2012·Journal of Neuro-oncology·Edward PanMarc Chamberlain
Jul 31, 2012·Japanese Journal of Clinical Oncology·Motoo NaganeMasao Matsutani
Aug 25, 2012·Journal of Neuro-oncology·Phioanh Leia NghiemphuTimothy F Cloughesy
Aug 28, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eudocia Q LeePatrick Y Wen
Oct 23, 2012·Journal of Neuro-oncology·Teri N KreislHoward A Fine
Oct 27, 2012·Neuro-oncology·Teri N KreislHoward A Fine
Nov 28, 2012·International Journal of Radiation Oncology, Biology, Physics·Arnab ChakravartiMinesh P Mehta
Nov 28, 2012·Journal of Neuro-oncology·Aida MuhicUlrik Lassen
Jan 19, 2013·Neuro-oncology·David M PeereboomNew Approaches to Brain Tumor Therapy Consortium
Feb 1, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David A ReardonJohann de Bono
Jun 4, 2013·International Journal of Radiation Oncology, Biology, Physics·Prakash ChinnaiyanMinesh P Mehta

Citations

Nov 2, 2015·Bioinformatics·Charlotte SiskaKaterina Kechris
Jul 22, 2014·Expert Opinion on Therapeutic Targets·Er-Bao BianBing Zhao
Oct 16, 2016·Scientific Reports·Benedikt WiestlerChristine Preibisch
Jul 13, 2017·Journal of Biomaterials Science. Polymer Edition·Wei HanZhongbing Huang
Aug 30, 2019·BMC Medical Genomics·Yongqin YinYu-Juan Zhang
May 21, 2019·Expert Review of Neurotherapeutics·Candice D CarpenterVinay K Puduvalli
Apr 19, 2019·Journal of Neuro-oncology·Faan MiaoYuechao Fan
Jul 12, 2017·Oncology Letters·Zhengwei LiFengli Liu

Related Concepts

Antineoplastic Agents
Clinical Trials
Mixed Gliomas
Central Nervous System Neoplasms, Primary
Molecular Targeted Therapy
Malignant Neoplasms
Diagnostic Techniques, Surgical
Glioma
Neoplasms
Signal Pathways

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