Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Frontiers of Medicine
Zhen WangChunyi Hao

Abstract

Desmoid-type fibromatosis (DF) is a rare monoclonal fibroblastic proliferation that is characterized by locally infiltrative but rarely metastatic lesions. Tyrosine kinase and γ-secretase inhibitors are primarily used in the targeted therapy of DF. The use of these drugs, however, is mainly based on the recommendations of retrospective studies with small sample sizes. Previous studies that focused on the mechanism, efficacy, and safety of targeted therapy for DF were reviewed to provide references for clinical applications and research. The efficacy and safety of targeted therapy were compared with those of other systemic therapy options. Targeted therapy does not provide considerable advantages in efficacy and safety over other medical treatments and is usually applied after the failure of antihormonal therapies, nonsteroidal anti-inflammatory drugs, and chemotherapy. Further studies are required to explore the mechanism, indications, and appropriate drug dosage of the targeted therapy of DF.

References

Feb 1, 1989·Archives of Surgery·M C PosnerM F Brennan
Jan 1, 1972·Journal of Surgical Oncology·J G JohnsonA L Watne
Aug 1, 1983·International Journal of Radiation Oncology, Biology, Physics·S A LeibelT L Phillips
Aug 15, 1994·Cancer·M A Rodriguez-BigasN J Petrelli
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·P ZagourasS Artavanis-Tsakonas
Apr 13, 1999·American Journal of Clinical Oncology·A J WeissR D Lackmen
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M T BalloR A Pollack
Mar 10, 2001·International Journal of Cancer. Journal International Du Cancer·L BertarioUNKNOWN Hereditary Colorectal Tumours Registry
Jun 25, 2002·Acta Orthopaedica Scandinavica·Annemette SørensenOlaf M Jensen
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A GronchiJ Rosai
Jan 28, 2004·Cancer·Anika HansmannGabriela Moeslein
Aug 16, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·John R ZalcbergUNKNOWN Australasian Gastrointestinal Trials Group
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Makoto GegaTakehira Yamamura
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C HeinrichJonathan A Fletcher
May 25, 2006·British Journal of Cancer·E WeisbergJ D Griffin
Oct 13, 2006·Current Treatment Options in Oncology·Scott Okuno
Apr 25, 2007·Journal of Cancer Research and Clinical Oncology·Gabriel WcisloCezary Szczylik
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dina LevRaphael E Pollock
Aug 22, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S BonvalotC Le Péchoux
Aug 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Monica M BertagnolliSuzanne George
Oct 4, 2008·The American Journal of Pathology·Alexander J F LazarDina Lev
Mar 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Verónica RodillaLluís Espinosa
Apr 22, 2009·Cell·Raphael Kopan, Maria Xenia G Ilagan
Sep 22, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anastasia ConstantinidouIan Judson
Nov 20, 2009·Biochimica Et Biophysica Acta·Paul W ManleyDoriano Fabbro
Jul 14, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N PenelJ-Y Blay
Aug 10, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Magali Lacroix-TrikiJorge S Reis-Filho
Aug 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rashmi ChughUNKNOWN Sarcoma Alliance for Research through Collaboration (SARC)
Sep 8, 2010·Bioorganic & Medicinal Chemistry·Paul W ManleyNeil Gallagher
Mar 30, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D GarbayA Italiano
Mar 31, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Claudia BrogsitterJörg Kotzerke
Mar 31, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mrinal M GounderRobert G Maki
Aug 13, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·D BocaleD F Altomare
Jul 7, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sophie Le GuellecJean-Michel Coindre
Aug 7, 2012·The Journal of Clinical Investigation·Hyun-A KimYoung-Yun Kong
Mar 28, 2013·Annals of Surgery·Aimeé M CragoMurray F Brennan

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Citations

Jan 17, 2021·Journal of Cancer Research and Clinical Oncology·Chuanxi ZhengLi Min
Aug 19, 2021·BMC Musculoskeletal Disorders·Costantino ErraniShinji Tsukamoto

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