Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium.

Cell Proliferation
H KimuraRobert M Hoffman

Abstract

Spinal cord tumours are highly malignant and often lead to paralysis and death due to their infiltrative nature, high recurrence rate and limited treatment options. In this study, we measured antitumour efficacy of the Salmonella typhimurium A1-R tumour-targeting bacterium strain, administered systemically or intrathecally, to spinal cord cancer in orthotopic mouse models. Tumour fragments of U87-RFP were implanted by surgical orthotopic implantation into the dorsal site of the spinal cord. Five and 10 days after transplantation, eight mice in each group were treated with A1-R (2 x 10(7) CFU/200 microL i.v. injection or 2 x 10(6) CFU/10 microL intrathecal injection). Untreated mice showed progressive paralysis beginning at day 6 after tumour transplantation and developed complete paralysis between 18 and 25 days. Mice treated i.v. with A1-R had onset of paralysis at approximately 11 days and at 30 days; five mice developed complete paralysis, while the other three mice had partial paralysis. Mice treated by intrathecal injection of A1-R had onset of paralysis at approximately 18 days and one mouse was still not paralysed at day 30. Only one mouse developed complete paralysis at day 30 in this group. Intrathecally treated animal...Continue Reading

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Citations

Jun 8, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sara Leschner, Siegfried Weiss
Feb 25, 2011·International Journal of Clinical Oncology·Norio YamamotoRobert M Hoffman
Oct 15, 2010·Nature Reviews. Cancer·Neil S Forbes
Jul 13, 2012·Cancer Discovery·Robert M Hoffman
Jun 29, 2014·The Journal of Surgical Research·Shinji MiwaRobert M Hoffman
Aug 8, 2012·World Journal of Surgical Oncology·Chen ShaoBaoxue Yang
Aug 24, 2013·Critical Reviews in Microbiology·Chao Zu, Jiansheng Wang
Sep 10, 2014·International Journal of Molecular Sciences·Wen-Wei Chang, Che-Hsin Lee
Jun 21, 2014·Expert Opinion on Drug Discovery·Robert M Hoffman, Ming Zhao
Jun 28, 2012·International Journal of Cancer. Journal International Du Cancer·Che-Hsin LeeWan-Lin Kuo
Apr 6, 2013·International Journal of Cancer. Journal International Du Cancer·Wen-Wei ChangChe-Hsin Lee
Sep 9, 2015·Future Microbiology·Zhao-Fei ChenJing-Yuan Fang
May 13, 2015·Letters in Applied Microbiology·S Wong, R A Slavcev
Apr 15, 2015·International Journal of Cancer. Journal International Du Cancer·Christian SternSiegfried Weiss
Aug 4, 2015·Neurosurgical Focus·Michael KarsyMark A Mahan
Apr 19, 2011·Current Opinion in Biotechnology·Robert M Hoffman
Oct 20, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shuya YanoRobert M Hoffman
Jun 23, 2016·Future Oncology·Catierine Hirsch WerleMarcelo Brocchi
Oct 10, 2012·Experimental Biology and Medicine·Wen-Wei ChangChe-Hsin Lee
Aug 27, 2016·Journal of Cellular Biochemistry·Robert M Hoffman
Sep 1, 2017·International Journal of Molecular Sciences·Robert M Hoffman
Dec 13, 2019·Experimental & Molecular Medicine·Mai Thi-Quynh DuongJung-Joon Min
May 5, 2016·Oncotarget·Cecilia A Silva-ValenzuelaMichael McClelland

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