Targeted therapy or immunotherapy? Optimal treatment in hepatocellular carcinoma

World Journal of Gastrointestinal Oncology
Merly Contratto, Jennifer Wu

Abstract

Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer mortality in the United States and the second leading cause of cancer mortality worldwide. Sorafenib is the only food and drug administration (FDA) approved as first line systemic treatment in HCC. Regorafenib and nivolumab are the only FDA approved second line treatment after progression on sorafenib. We will discuss all potential first and second line options in HCC. In addition, we also will explore sequencing treatment options in HCC, and examine biomarkers that can potentially predict benefits from treatments such as immune checkpoint inhibitor. This minireview summarizes potential treatments in HCC based on clinical trials that have been published in manuscript or abstract format from 1994-2018.

References

Mar 17, 2001·International Journal of Cancer. Journal International Du Cancer·T ShinM Taniguchi
Sep 28, 2001·Trends in Immunology·D M FruchtS Koyasu
Oct 4, 2003·Journal of Leukocyte Biology·Kate SchroderDavid A Hume
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Jan 16, 2009·The Oncologist·Matthias PinterMarkus Peck-Radosavljevic
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qiang GaoJia Fan
Feb 7, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dominik BettingerHans Christian Spangenberg
May 2, 2012·American Journal of Clinical Oncology·Bassam EstfanRichard Kim
Jun 12, 2013·International Journal of Cancer. Journal International Du Cancer·I-Cheng LeeHan-Chieh Lin
Nov 20, 2014·The New England Journal of Medicine·Alexandra SnyderTimothy A Chan
Oct 6, 2016·Journal of Gastroenterology·Kenji IkedaHiromitsu Kumada
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Aug 24, 2018·Chembiochem : a European Journal of Chemical Biology·Xiaohong Cen, Kui Cheng
Sep 19, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Zhi LiuJian Shui Li
Nov 6, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·T MocanD C Leucuta
Jun 18, 2020·Frontiers in Immunology·Yu-Chen ChuangTsung-Hsien Chuang
Aug 25, 2020·Journal of Clinical and Translational Hepatology·Shima GhavimiNikolaos T Pyrsopoulos
Oct 25, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Ching Ngar WongDavid J Pinato

❮ Previous
Next ❯

Methods Mentioned

BETA
exome sequencing
biopsy

Software Mentioned

POPLAR

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

© 2022 Meta ULC. All rights reserved