Targeted total marrow irradiation using three-dimensional image-guided tomographic intensity-modulated radiation therapy: an alternative to standard total body irradiation

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Jeffrey Y C WongGeorge Somlo

Abstract

Total body irradiation (TBI) is an important part of bone marrow transplantation conditioning regimens. In TBI, dose escalation is difficult, because of associated normal organ toxicities. A method to deliver a more targeted dose of TBI preferentially to sites of greatest tumor burden is needed to reduce the dose to normal organs, reduce toxicities, and permit dose escalation. The purpose of this study was to evaluate, through a dosimetric analysis, the potential advantages and feasibility of selectively delivering targeted myeloablative doses of radiation to bone and marrow using a recently developed image-guided tomographic intensity-modulated radiation therapy delivery system (helical tomotherapy). Whole-body computed tomography datasets from 3 patients, age 5, 20, and 53 years, were used for treatment planning studies to evaluate 2 targeted TBI strategies: total marrow irradiation (TMI), in which the target region was defined as the skeletal bone, and total marrow and lymphoid irradiation (TMLI), in which the target regions were defined as bone, major lymph node chains, liver, spleen, and sanctuary sites, such as brain. Organ doses and dose distributions were compared with those in conventional TBI. A 1.7- to 7.5-fold reduc...Continue Reading

References

Dec 1, 1992·Acta Paediatrica·G LönnerholmT H Tötterman
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·F B PetersenK M Sullivan
Nov 1, 1983·International Journal of Radiation Oncology, Biology, Physics·B ShankR J O'Reilly
Aug 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J L Pino y TorresS E Order
Aug 1, 1981·International Journal of Radiation Oncology, Biology, Physics·B ShankR J O'Reilly
Sep 30, 1995·International Journal of Radiation Oncology, Biology, Physics·D OetzelM Flentje
Nov 15, 1994·International Journal of Radiation Oncology, Biology, Physics·T GirinskyE Gluckman
Apr 10, 1999·Seminars in Radiation Oncology·T R MackieM Mehta
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·M V GrahamC A Perez
Feb 3, 2000·International Journal of Radiation Oncology, Biology, Physics·D ZierhutM Wannenmacher
Dec 29, 2000·Physics in Medicine and Biology·K J RuchalaT R Mackie
Jan 21, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Theresa HahnPhilip L McCarthy
Jun 14, 2003·Cancer Biotherapy & Radiopharmaceuticals·Hazel BreitzBarry Wessels
Jul 30, 2003·Physics in Medicine and Biology·G GrigorovG Rodrigues
Apr 27, 2004·The British Journal of Radiology·A W Beavis
Sep 28, 2004·Physics in Medicine and Biology·Tomas KronJake Van Dyk

❮ Previous
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Citations

Mar 13, 2008·Bone Marrow Transplantation·A Stein, S J Forman
May 28, 2013·Bone Marrow Transplantation·C AristeiUNKNOWN Italian TBI Working Group
Apr 26, 2011·Japanese Journal of Clinical Oncology·Ik Jae LeeKwang Hyub Han
May 26, 2011·The Cancer Journal·Jian-Yue JinIndrin J Chetty
Nov 5, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·George SomloJeffrey Y C Wong
Nov 14, 2012·Radiation Oncology·Sonja KrauseFlorian Sterzing
Nov 19, 2013·PloS One·Chotima BöttcherJosef Priller
Jan 1, 2007·Biomedical Imaging and Intervention Journal·S YartsevJ Van Dyk
Apr 23, 2011·World Journal of Radiology·Youlia M Kirova, Cyrus Chargari
Apr 2, 2011·Medical Physics·Amjad HussainDerek W Brown
Sep 3, 2014·The Journal of Experimental Medicine·Allison L BoydMickie Bhatia
May 6, 2009·In Vivo·Joel S Greenberger
Oct 13, 2015·Biochimica Et Biophysica Acta·Chotima Böttcher, Josef Priller
Jul 16, 2014·Expert Review of Hematology·Giuseppe VisaniAlessandro Isidori
Feb 24, 2011·Expert Review of Anticancer Therapy·Yi Rong, James S Welsh
Sep 10, 2013·International Journal of Radiation Oncology, Biology, Physics·Yutaka TakahashiSusanta K Hui
Nov 19, 2011·Hematology/oncology Clinics of North America·Oana Paun, Hillard M Lazarus
Feb 25, 2011·International Journal of Radiation Oncology, Biology, Physics·Bulent AydoganKim Gwe-Ya
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Antonella FogliataMarta Scorsetti
Nov 3, 2010·International Journal of Radiation Oncology, Biology, Physics·Mete YeginerBulent Aydogan
Oct 15, 2009·Hematology/oncology Clinics of North America·Stephen J Forman
Nov 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Florian SterzingGustavo Oliveira
Dec 1, 2009·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Audrey H ZhuangJeffrey Y C Wong
Jul 21, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·T ZilliM Ozsahin
Dec 17, 2008·International Journal of Radiation Oncology, Biology, Physics·Ik Jae LeeJaeho Cho
Oct 27, 2007·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G KantorA Mazal
Sep 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Ralf A SchneiderRazvan M Galalae
Sep 23, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Pritesh PatelDamiano Rondelli
Dec 15, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christopher WilkeSusanta Hui
Apr 21, 2007·International Journal of Radiation Oncology, Biology, Physics·Amol GhiaMinesh P Mehta
Mar 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Timothy E SchultheissGeorge Somlo
Jul 5, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Chunhui HanJeffrey Y C Wong
Feb 20, 2015·Journal of Radiation Research·Rezvan AzimiSusanta K Hui
Sep 18, 2014·International Journal of Radiation Oncology, Biology, Physics·Matthew D HallJeffrey Y C Wong

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