Targeted treatment with pazopanib in metastatic soft tissue sarcoma: Nearly complete response in two cases

Molecular and Clinical Oncology
Ali Murat SedefÖzgur Özyilkan

Abstract

Soft tissue sarcomas (STS) are a group of rare mesenchymal cancers that include approximately 50 histological types and account for 1% of all adult cancers. The standard curative treatment option for localized disease is surgical resection and, if a surgically removed tumor exhibits high-risk characteristics, adjuvant chemotherapy and radiotherapy may be administered. Sarcoma presenting at an advanced stage has a dismal prognosis and survival has not markedly improved over the last 20 years. The standard first-line treatment for advanced STS, other than gastrointestinal stromal tumors, is cytotoxic chemotherapy. Therapies targeting pro-angiogenic factors have been a focus of drug development for STS over the last few years. Pazopanib, a multitargeted tyrosine kinase inhibitor, is a novel treatment option for patients with metastatic STS in the second-line setting. This is a presentation of 2 case reports of patients with metastatic STS who responded well to treatment with pazopanib.

References

Aug 20, 2002·The Oncologist·Alexander I Spira, David S Ettinger
Apr 6, 2004·CA: a Cancer Journal for Clinicians·Janice N Cormier, Raphael E Pollock
Aug 19, 2005·The New England Journal of Medicine·Matthew A ClarkJ Meirion Thomas
Sep 15, 2009·Indian Journal of Cancer·A JainK C Lakshmaiah
May 12, 2010·Critical Reviews in Oncology/hematology·Fabio A B SchutzCora N Sternberg
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P G CasaliUNKNOWN ESMO/CONTICANET/EUROBONET Consensus Panel of experts
Jul 17, 2010·Sarcoma·Robert GrimerBeatrice Seddon
Oct 15, 2010·Cancer·Antoine ItalianoBinh Bui
Jun 22, 2012·Expert Review of Anticancer Therapy·Patrick Schöffski

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