Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts.

Biomolecules
Margaux TeilBenjamin Dehay

Abstract

Parkinson's Disease (PD) is characterized both by the loss of dopaminergic neurons in the substantia nigra and the presence of cytoplasmic inclusions called Lewy Bodies. These Lewy Bodies contain the aggregated α-synuclein (α-syn) protein, which has been shown to be able to propagate from cell to cell and throughout different regions in the brain. Due to its central role in the pathology and the lack of a curative treatment for PD, an increasing number of studies have aimed at targeting this protein for therapeutics. Here, we reviewed and discussed the many different approaches that have been studied to inhibit α-syn accumulation via direct and indirect targeting. These analyses have led to the generation of multiple clinical trials that are either completed or currently active. These clinical trials and the current preclinical studies must still face obstacles ahead, but give hope of finding a therapy for PD with time.

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Citations

Jul 19, 2020·Reviews on Environmental Health·Abbas MohammadipourAlireza Ebrahimzadeh Bideskan
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Datasets Mentioned

BETA
PRX002

Methods Mentioned

BETA
transgenic
antisense oligonucleotide
glycosylation
ubiquitination
acetylation
transfection

Clinical Trials Mentioned

NCT03100149
NCT03272165
NCT03318523
NCT04127695
NCT02606682
NCT04208152
NCT00740714

Software Mentioned

Affitopes

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

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