Targeting a Novel ER/HOXB7 Signaling Loop in Tamoxifen-Resistant Breast Cancer

Cancer Discovery
Marinus R HeidemanNancy E Hynes

Abstract

The majority of patients with breast cancer present with an estrogen receptor-positive (ER(+)) tumor, and the endocrine agent tamoxifen is a mainstay for their treatment. Unfortunately, however, resistance remains a major problem because most patients who respond eventually have a recurrence. Thus, an enduring challenge in the breast cancer field is to identify mechanisms underlying tamoxifen resistance. Jin and colleagues describe a novel ER/HOXB7 signaling loop in tamoxifen-resistant breast cancer models. Importantly, they reveal that targeting this signaling loop has great promise as an approach to treat patients with tamoxifen-resistant breast cancer.

References

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Jul 1, 2015·Nature Reviews. Clinical Oncology·Rinath JeselsohnRachel Schiff

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Citations

Jun 7, 2019·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Xia ChengGang Deng
Jan 22, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Longfei DaiShusen Zheng
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Xingang ZhouPeng Wang

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