Targeting acquired oncogenic burden in resilient pancreatic cancer: a novel benefit from marine polyphenols.

Molecular and Cellular Biochemistry
Sheeja AravindanNatarajan Aravindan

Abstract

The upsurge of marine-derived therapeutics for cancer treatment is evident, with many drugs in clinical use and in clinical trials. Seaweeds harbor large amounts of polyphenols and their anti-cancer benefit is linear to their anti-oxidant activity. Our studies identified three superlative anti-cancer seaweed polyphenol drug candidates (SW-PD). We investigated the acquisition of oncogenic burden in radiation-resilient pancreatic cancer (PC) that could drive tumor relapse, and elucidated the efficacy of SW-PD candidates as adjuvants in genetically diverse in vitro systems and a mouse model of radiation-residual disease. QPCR profiling of 88 oncogenes in therapy-resilient PC cells identified a 'shared' activation of 40 oncogenes. SW-PD pretreatment inflicted a significant mitigation of acquired (shared) oncogenic burden, in addition to drug- and cell-line-specific repression signatures. Tissue microarray with IHC of radiation-residual tumors in mice signified acquired cellular localization of key oncoproteins and other critical architects. Conversely, SW-PD treatment inhibited the acquisition of these critical drivers of tumor genesis, dissemination, and evolution. Heightened death of resilient PC cells with SW-PD treatment valida...Continue Reading

References

Jan 15, 1987·International Journal of Cancer. Journal International Du Cancer·D R CoombeJ M Snowden
Nov 13, 2001·Oncogene·T Crnogorac-JurcevicN R Lemoine
Dec 12, 2003·Nature Reviews. Cancer·Robert Eferl, Erwin F Wagner
Jul 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jörg KöningerHelmut Friess
Apr 19, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yvonne V YuanNatalie A Walsh
Oct 4, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Karin Milde-Langosch
Mar 24, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yvonne V Yuan, Natalie A Walsh
Mar 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jin-Ping LaiLewis R Roberts
Mar 26, 2009·Journal of the National Cancer Institute·Nadia HowladerBrenda K Edwards
Oct 27, 2009·Oncogene·H Lemjabbar-AlaouiS D Rosen
Jan 1, 2010·Journal of Oncology·N Sithranga Boopathy, K Kathiresan
Jun 15, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing-Iong YangHsueh-Wei Chang
Apr 16, 2013·Clinical & Experimental Metastasis·Sheeja AravindanNatarajan Aravindan
Sep 13, 2013·British Journal of Pharmacology·C GüngörM Bockhorn
Oct 1, 2013·BioMed Research International·Farideh NamvarHeshu Sulaiman Rahman
Feb 11, 2014·Bioorganic & Medicinal Chemistry·Lauren DysonAdam McCluskey
May 2, 2014·Environmental Toxicology and Pharmacology·Noel Vinay ThomasSe-Kwon Kim
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Hala Yassin El-Kassas, Mostafa M El-Sheekh
Jul 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Peter S ChoiDean W Felsher
Dec 17, 2014·Cancer Letters·Han-xiang ZhanSan-yuan Hu
Dec 30, 2014·International Journal of Biological Macromolecules·Caroline R DelmaNatarajan Aravindan
Apr 22, 2015·Journal of Biomedical Science·Sheeja AravindanNatarajan Aravindan
Jan 1, 2014·Frontiers in Molecular Biosciences·Rajamanickam BaskarKheng-Wei Yeoh
Aug 25, 2015·Cancer Science·Kozo NoguchiHideshi Ishii
Dec 15, 2015·British Journal of Cancer·Sanjeev K SrivastavaAjay P Singh
Dec 23, 2015·International Journal of Oncology·Eriko KatsutaMinoru Tanabe
Feb 20, 2016·Oncotarget·Chan-Hun JungHong-Duck Um
Jun 4, 2016·Bioorganic & Medicinal Chemistry Letters·Wan-Ru TsengJyh-Horng Sheu

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Citations

May 18, 2021·Bioactive Materials·Mei-Chen WanLi-Na Niu

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Methods Mentioned

BETA
xenograft
xenografts
profiler
PCR
RNA-seq
transgenic

Software Mentioned

GraphPad PRISM
Aperio
Realtimeprimers
MZcloud
R2 Analysis and Visualization Platform
Aperio Integrated Spectrum
IPA

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