Targeting ALK in Cancer: Therapeutic Potential of Proapoptotic Peptides

Cancers
Arthur AubryMichèle Allouche

Abstract

ALK is a receptor tyrosine kinase, associated with many tumor types as diverse as anaplastic large cell lymphomas, inflammatory myofibroblastic tumors, breast and renal cell carcinomas, non-small cell lung cancer, neuroblastomas, and more. This makes ALK an attractive target for cancer therapy. Since ALK⁻driven tumors are dependent for their proliferation on the constitutively activated ALK kinase, a number of tyrosine kinase inhibitors have been developed to block tumor growth. While some inhibitors are under investigation in clinical trials, others are now approved for treatment, notably in ALK-positive lung cancer. Their efficacy is remarkable, however limited in time, as the tumors escape and become resistant to the treatment through different mechanisms. Hence, there is a pressing need to target ALK-dependent tumors by other therapeutic strategies, and possibly use them in combination with kinase inhibitors. In this review we will focus on the therapeutic potential of proapoptotic ALK-derived peptides based on the dependence receptor properties of ALK. We will also try to make a non-exhaustive list of several alternative treatments targeting ALK-dependent and independent signaling pathways.

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Citations

Feb 11, 2020·Chemical Society Reviews·Jingying LiHuanghao Yang
Feb 16, 2020·Cancers·Lan Wang, Vivian Wai Yan Lui
Mar 4, 2020·Expert Opinion on Therapeutic Patents·Yi-Min LiuJing-Ping Liou
Jan 14, 2020·Cancer Metastasis Reviews·Gian Paolo Tonini, Mario Capasso
Sep 27, 2019·Pediatric Blood & Cancer·Elvis T ValeraLuiz Gonzaga Tone
Jul 22, 2019·Cancer Treatment Reviews·Ting-Hui WuJames Chih-Hsin Yang
Jul 3, 2021·International Journal of Molecular Sciences·Karolina StachyraAnna M Czarnecka
Feb 3, 2022·JCO Precision Oncology·Priscila Barreto-CoelhoGina Z D'Amato

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Methods Mentioned

BETA
surface plasmon resonance
xenograft

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