Targeting ALK in neuroblastoma--preclinical and clinical advancements.

Nature Reviews. Clinical Oncology
Erica L Carpenter, Yael P Mosse

Abstract

Despite improvements in cancer therapies in the past 50 years, neuroblastoma remains a devastating clinical problem and a leading cause of childhood cancer deaths. Advances in treatments for children with high-risk neuroblastoma have, until recently, involved addition of cytotoxic therapy to dose-intensive regimens. In this era of targeted therapies, substantial efforts have been made to identify optimal targets for different types of cancer. The discovery of hereditary and somatic activating mutations in the oncogene ALK has now placed neuroblastoma among other cancers, such as melanoma and non-small-cell lung cancer (NSCLC), which benefit from therapies with oncogene-specific small-molecule tyrosine kinase inhibitors. Crizotinib, a small-molecule inhibitor of ALK, has transformed the landscape for the treatment of NSCLC harbouring ALK translocations and has demonstrated activity in preclinical models of ALK-driven neuroblastomas. However, inhibition of mutated ALK is complex when compared with translocated ALK and remains...Continue Reading

References

May 1, 1986·The Journal of Pathology·B OzanneB Gusterson
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M SchwabJ M Bishop
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J BaselgaL Norton
Jan 1, 1997·Journal of Neuro-oncology·G M BrodeurA E Evans
Jun 2, 1997·The EMBO Journal·W A WeissJ M Bishop
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K YamamotoY Hayashi
May 4, 2000·The American Journal of Pathology·L LamantB Mariamé
Mar 30, 2001·The Journal of Biological Chemistry·G E StoicaA Wellstein
Jul 4, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F RobertH W Waksal
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Willy G DirksHans G Drexler
Jul 18, 2002·The Journal of Biological Chemistry·Gerald E StoicaAnton Wellstein
Mar 4, 2003·Nature Reviews. Cancer·Garrett M Brodeur
Jun 12, 2003·International Journal of Cancer. Journal International Du Cancer·Roberta VitaliCarlo Dominici
Sep 18, 2003·Journal of the National Cancer Institute·Catherine A BurkhartMichelle Haber
Jan 8, 2004·Journal of the National Cancer Institute·Kiichiro BeppuCarol J Thiele
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Feb 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sae-Won HanNoe Kyeong Kim
May 17, 2005·Nature Medicine·Roberto ChiarleGiorgio Inghirami
Jun 24, 2005·The American Journal of Pathology·Yuko Osajima-HakomoriRyuichi Sakai
Nov 25, 2005·The New England Journal of Medicine·Edward F AttiyehUNKNOWN Children's Oncology Group
Jun 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Monika KasprzyckaMariusz A Wasik
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Anna V GalkinMarkus Warmuth
Apr 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andy J ChengMichelle Haber
Apr 26, 2007·Pediatric Blood & Cancer·John M MarisMalcolm A Smith
Jan 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey M SkolnikPeter C Adamson
Feb 20, 2008·Neoplasia : an International Journal for Oncology Research·Itay ShafatBenjamin Nisman
Mar 8, 2008·Current Opinion in Genetics & Development·Jeffrey A Engelman, Jeffrey Settleman
Oct 17, 2008·Nature·Isabelle Janoueix-LeroseyOlivier Delattre

❮ Previous
Next ❯

Citations

Feb 26, 2013·The Lancet Oncology·Gilles VassalPeter C Adamson
Dec 3, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bin YiLizhong Wang
Jun 26, 2013·Experimental and Molecular Pathology·Miao WangLiping Gong
Dec 2, 2014·Pediatric Clinics of North America·Meredith S Irwin, Julie R Park
Sep 17, 2014·Nature Reviews. Clinical Oncology·Peter C AdamsonKathy Pritchard-Jones
Nov 12, 2013·British Medical Bulletin·Lucas MorenoAndrew D J Pearson
Jan 7, 2014·Expert Opinion on Therapeutic Targets·Garrett M BrodeurVenkatadri Kolla
May 23, 2013·Expert Opinion on Emerging Drugs·Victoria CastelPablo Berlanga
Feb 2, 2013·The Lancet Oncology·Lia GoreChristopher C Porter
Aug 28, 2012·Cancer Letters·Gian Paolo ToniniFrank Berthold
May 8, 2013·Pediatric Blood & Cancer·Kaleem AshrafMeredith S Irwin
Mar 24, 2016·Nature Reviews. Clinical Oncology·Agnès BuzynGilles Vassal
Feb 6, 2015·Cancer Medicine·Valérie CombaretJean Yves Blay
Sep 21, 2012·The Biochemical Journal·Stephen C ArtimMark A Lemmon
May 30, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Monica LoiFabio Pastorino
Feb 5, 2013·Pediatric Hematology and Oncology·Maryam Afshar, Carla Golden
Mar 26, 2015·Immunotherapy·Michela CroceSilvano Ferrini
Dec 3, 2014·Biochemical and Biophysical Research Communications·Fei XuYong Sun
Aug 28, 2014·Frontiers in Oncology·Inge M AmbrosPeter F Ambros
Apr 18, 2015·PLoS Computational Biology·Juan Palacios-MorenoMark L Grimes
Jul 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gudrun SchleiermacherTommy Martinsson
Jan 5, 2017·Cold Spring Harbor Molecular Case Studies·Vijaykumar R HollaGeorge R Simon
Dec 24, 2013·Current Opinion in Pediatrics·Pamela Kearns, Bruce Morland
Mar 23, 2017·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Eun Kyung Kim, Sewha Kim
Nov 28, 2017·Current Opinion in Pediatrics·Andrea Flynn, Elizabeth Fox
Apr 19, 2018·International Journal of Cancer. Journal International Du Cancer·Wenxin LuoWeimin Li
Jul 12, 2018·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Januária Nunes LucenaEliana Maria Monteiro Caran
Sep 27, 2018·Pediatric Blood & Cancer·Monish R MakenaC Patrick Reynolds
Feb 26, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ganesh UmapathyRuth H Palmer
Sep 26, 2013·Nature Reviews. Cancer·Bengt Hallberg, Ruth H Palmer
May 25, 2013·Nature Reviews. Cancer·Nai-Kong V Cheung, Michael A Dyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.