Targeting AMPK signaling in combating ovarian cancers: opportunities and challenges.

Acta Biochimica Et Biophysica Sinica
Mingo M H YungDavid W Chan

Abstract

The development and strategic application of effective anticancer therapies have turned out to be one of the most critical approaches of managing human cancers. Nevertheless, drug resistance is the major obstacle for clinical management of these diseases especially ovarian cancer. In the past years, substantial studies have been carried out with the aim of exploring alternative therapeutic approaches to enhance efficacy of current chemotherapeutic regimes and reduce the side effects caused in order to produce significant advantages in overall survival and to improve patients' quality of life. Targeting cancer cell metabolism by the application of AMP-activated protein kinase (AMPK)-activating agents is believed to be one of the most plausible attempts. AMPK activators such as 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside, A23187, metformin, and bitter melon extract not only prevent cancer progression and metastasis but can also be applied as a supplement to enhance the efficacy of cisplatin-based chemotherapy in human cancers such as ovarian cancer. However, because of the undesirable outcomes along with the frequent toxic side effects of most pharmaceutical AMPK activators that have been utilized in clinical trials, atte...Continue Reading

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Citations

Jan 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Taek-In OhJi-Hong Lim
Aug 9, 2020·OncoTargets and Therapy·Wei HanWei Guan
Jan 4, 2021·Biochemical and Biophysical Research Communications·Yusuke TakahashiTetsuji Naka
Aug 20, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·David W ChanHextan Ys Ngan
Aug 14, 2021·European Journal of Medicinal Chemistry·Xin QiaoJing-Yuan Xu
Oct 15, 2021·Oncogene·Dongqing HuangAmanda G Paulovich

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