PMID: 25777274Mar 18, 2015Paper

Targeting AMPK Signaling Pathway to Overcome Drug Resistance for Cancer Therapy

Current Drug Targets
Zhiyu WangYi Lin

Abstract

Mulitdrug resistance (MDR) is one of critical factorslimiting the efficacy of cancer chemoor radiotherapy. Emerging evidence has indicated that MDR is a complex process regulated by multiple factors, among which stress response molecules are considered as central players. AMP-activated protein kinase (AMPK) is a major regulator balancing energy supply and ultimately protects cells from harmful stresses via coordinating multiple metabolic pathways Notably, AMPK activation was recently shown to mediate the metabolism reprogramming in drug resistant cancer cells including promoting Warburg effects and mitochondrial biogenesis. Furthermore, AMPK activity has also been shown to regulate the self-renewal ability of cancer stem cells that are often refractory to chemotherapy. In addition, AMPK phosphorylation was critical in mediating autophagy induction, a process demonstrated to be effective in chemosensitivity modulation via degrading cellular components to satisfy nutrients requirement under stressful condition. Meanwhile, drug discovery targeting AMPK has been developed to validate the pathological significance of AMPK in cancer prevention and treatment. Although conflicting evidence focusing on the AMPK modulation for cancer tre...Continue Reading

Citations

Oct 26, 2016·International Journal of Oncology·Wei-Ching ChenMing-Derg Lai
Oct 4, 2017·Theoretical Biology & Medical Modelling·Youcef Derbal
Jun 21, 2018·International Journal of Molecular Sciences·Safa ShaheenDietrich Büsselberg
May 14, 2020·Journal of Experimental & Clinical Cancer Research : CR·Gennaro CilibertoMarco G Paggi
May 19, 2019·Journal of Experimental & Clinical Cancer Research : CR·Silvia MatteoniMarco G Paggi
Nov 29, 2017·Journal of Experimental & Clinical Cancer Research : CR·Claudia AbbruzzeseMarco G Paggi
Jan 8, 2020·Nutrients·Maria CastejónAlberto Diaz-Ruiz
May 19, 2020·British Journal of Cancer·Eric P AllainChantal Guillemette
Dec 24, 2015·Oxidative Medicine and Cellular Longevity·Alex Lyakhovich, Matilde E Lleonart

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