Targeting anaplastic lymphoma kinase in neuroblastoma

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Ganesh UmapathyRuth H Palmer

Abstract

Over the last decade, anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase (RTK), has been identified as a fusion partner in a diverse variety of translocation events resulting in oncogenic signaling in many different cancer types. In tumors where the full-length ALK RTK itself is mutated, such as neuroblastoma, the picture regarding the role of ALK as an oncogenic driver is less clear. Neuroblastoma is a complex and heterogeneous tumor that arises from the neural crest derived peripheral nervous system. Although high-risk neuroblastoma is rare, it often relapses and becomes refractory to treatment. Thus, neuroblastoma accounts for 10-15% of all childhood cancer deaths. Since most cases are in children under the age of 2, understanding the role and regulation of ALK during neural crest development is an important goal in addressing neuroblastoma tumorigenesis. An impressive array of tyrosine kinase inhibitors (TKIs) that act to inhibit ALK have been FDA approved for use in ALK-driven cancers. ALK TKIs bind differently within the ATP-binding pocket of the ALK kinase domain and have been associated with different resistance mutations within ALK itself that arise in response to therapeutic use, particularly in ALK-fusion p...Continue Reading

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Citations

Dec 20, 2019·Scientific Reports·Diana Cervantes-MadridBengt Hallberg
Jan 8, 2021·The EMBO Journal·Marcus BorenäsRuth H Palmer
May 1, 2021·Cancers·Joachim T SiawJikui Guan
Jun 10, 2021·Journal of Experimental & Clinical Cancer Research : CR·Vid MlakarFabienne Gumy-Pause
Jun 12, 2021·Seminars in Cancer Biology·Mirjam Blattner-JohnsonElke Pfaff
Jul 18, 2021·Journal of Molecular Biology·Ezgi UçkunRuth H Palmer
Aug 28, 2021·International Journal of Molecular Sciences·Godfred O Sabbih, Michael K Danquah
Oct 9, 2021·Journal of Molecular Biology·Ezgi UçkunRuth H Palmer
Oct 31, 2021·Cancer Metastasis Reviews·Esteban Javier Rozen, Jason Matthew Shohet

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Methods Mentioned

BETA
chromosomal aberrations

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