Targeting angiogenesis and lymphangiogenesis in kidney disease

Nature Reviews. Nephrology
Katsuyuki TanabeYasufumi Sato

Abstract

The kidney is permeated by a highly complex vascular system with glomerular and peritubular capillary networks that are essential for maintaining the normal functions of glomerular and tubular epithelial cells. The integrity of the renal vascular network depends on a balance of proangiogenic and antiangiogenic factors, and disruption of this balance has been identified in various kidney diseases. Decreased levels of the predominant proangiogenic factor, vascular endothelial growth factor A (VEGFA), can result in glomerular microangiopathy and contribute to the onset of preeclampsia, whereas upregulation of VEGFA has roles in diabetic kidney disease (DKD) and polycystic kidney disease (PKD). Other factors that regulate angiogenesis, such as angiopoietin 1 and vasohibin 1, have been shown to be protective in animal models of DKD and renal fibrosis. The renal lymphatic system is important for fluid homeostasis in the kidney, as well as the transport of immune cells and antigens. Experimental studies suggest that the lymphangiogenic factor VEGFC might have protective effects in PKD, DKD and renal fibrosis. Understanding the physiological and pathological roles of factors that regulate angiogenesis and lymphangiogenesis in the kidne...Continue Reading

References

Dec 1, 1992·Kidney International·L F BrownS Rosen
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Mar 6, 2003·The Journal of Clinical Investigation·Vera EreminaSusan E Quaggin
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
Jul 16, 2004·Human Molecular Genetics·Aino UtriainenTaina Pihlajaniemi
Feb 3, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yoshinobu KanesakiTsuyoshi Watanabe
Mar 4, 2005·Molecular and Cellular Biology·Megan E BaldwinMarc G Achen
Apr 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexander G Marneros, Bjorn R Olsen
Mar 10, 2006·American Journal of Physiology. Renal Physiology·R R FosterS J Harper
Jan 5, 2007·Journal of the American Society of Nephrology : JASN·Takahiko NakagawaByron Croker
Jun 8, 2007·Journal of the American Society of Nephrology : JASN·Enqi LiuJianglin Fan
Jun 23, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Michael T DellingerRobert P Erickson
Jul 13, 2007·Journal of the American Society of Nephrology : JASN·Belinda DavisLuigi Gnudi
Jul 20, 2007·Journal of the American Society of Nephrology : JASN·Isaac E Stillman, S Ananth Karumanchi
Sep 21, 2007·Kidney International·Y TaoC L Edelstein
Mar 14, 2008·The New England Journal of Medicine·Vera EreminaSusan E Quaggin
Apr 9, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sumathy MohanSherry L Abboud-Werner
Jul 9, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Waichi SatoTakahiko Nakagawa
Sep 19, 2008·American Journal of Physiology. Renal Physiology·Ellen C LeonardDavid P Basile
Sep 19, 2008·Journal of the American Society of Nephrology : JASN·Adrian S WoolfDavid A Long
Dec 2, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Toshiko FujimuraSeiya Okuda
May 20, 2009·The Journal of Cell Biology·Mark WinderlichDietmar Vestweber
Jun 6, 2009·The American Journal of Pathology·Tomoko HosakaYasufumi Sato
Jun 23, 2009·Journal of Cellular and Molecular Medicine·Astrid BergmannHerbert A Weich
Feb 17, 2010·The Biochemical Journal·Clément FayeSylvie Ricard-Blum
Feb 20, 2010·Journal of the American Society of Nephrology : JASN·Thijs W Cohen TervaertUNKNOWN Renal Pathology Society
May 7, 2010·Nature·Suphansa SawamiphakAmparo Acker-Palmer
Jun 12, 2010·Journal of the American Society of Nephrology : JASN·Shenhong WuXiaolei Zhu
Jul 10, 2010·Journal of the American Society of Nephrology : JASN·Yuki HamanoShiro Ueda
Jul 27, 2010·Trends in Cell Biology·Evangelia PardaliPeter ten Dijke
Jul 27, 2010·American Journal of Physiology. Heart and Circulatory Physiology·José M López-Novoa, Carmelo Bernabeu
Nov 4, 2010·Nature Reviews. Nephrology·Takahiko NakagawaQiuhong Li
Dec 3, 2010·American Journal of Physiology. Renal Physiology·David P BasileTimothy A Sutton
Feb 11, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alejandro R Chade
Apr 7, 2011·Blood·Sara I Cunha, Kristian Pietras
May 25, 2011·The Journal of Clinical Investigation·Marie JeanssonSusan E Quaggin

❮ Previous
Next ❯

Citations

Jul 2, 2020·International Journal of Molecular Sciences·Hiromasa MiyakeJun Wada
Oct 8, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Suraj KrishnanRajesh Mohandas
Nov 25, 2020·Archives of Pharmacal Research·Ji-Hak JeongYou Mie Lee
Feb 12, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yaping XiaoXuegang Li
Mar 27, 2021·Nature Reviews. Nephrology·Sébastien J DumasPeter Carmeliet
Apr 13, 2021·Frontiers in Medicine·Nassim MahtalPierre-Louis Tharaux
May 1, 2021·Diagnostics·Margaux Van WynsbergheCarole Henique
May 22, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Laurence M BlackTarek M El-Achkar
May 21, 2021·KI Reports·Aghilès HamrounArnaud Lionet
Aug 19, 2021·Expert Opinion on Pharmacotherapy·Andrea MarchettiMatteo Santoni
Sep 24, 2021·Journal of the American Society of Nephrology : JASN·Hao LiuDenise K Marciano

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
transgenic
gene knockout

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Yan-Lin RenFu-Er Lu
Journal of Clinical Medicine
Nuria Garcia-FernandezMaría José Soler
The American Journal of the Medical Sciences
Aidar R GosmanovElvira O Gosmanova
Toxicologic Pathology
Kathleen M Heinz-TahenyJosef G Heuer
© 2021 Meta ULC. All rights reserved