Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression

Theranostics
Shih-Chieh LinShaw-Jenq Tsai

Abstract

Rationale: Endometriosis is a highly prevalent gynecological disease in women of reproductive age that markedly reduces life quality and fertility. Unfortunately, there is no cure for this disease, which highlights that more efforts are needed to investigate the underlying mechanism for designing novel therapeutic regimens. This study aims to investigate druggable membrane receptors distinctively expressed in endometriotic cells. Methods: Bioinformatic analysis of public databases was employed to identify potential druggable candidates. Normal endometrial tissues and ectopic endometriotic lesions were obtained for the determination of target genes. Primary endometrial and endometriotic stromal cells as well as two different mouse models of endometriosis were used to characterize molecular mechanisms and therapeutic outcomes of endometriosis, respectively. Results: Anthrax toxin receptor 2 (ANTXR2) mRNA and protein are upregulated in the endometriotic specimens. Elevation of ANTXR2 promotes endometriotic cell adhesion, proliferation, and angiogenesis. Furthermore, hypoxia is the driving force for ANTXR2 upregulation via altering histone modification of ANTXR2 promoter by reducing the repressive mark, histone H3 lysine 27 (H3K27)...Continue Reading

Citations

Jan 9, 2019·The Journal of Obstetrics and Gynaecology Research·Meng-Hsing WuShaw-Jenq Tsai
May 12, 2020·Journal of Biomedical Science·Pai-Sheng ChenShaw-Jenq Tsai
Oct 3, 2020·Proceedings of the National Academy of Sciences of the United States of America·Wan-Ning LiShaw-Jenq Tsai
Mar 23, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liukun MengXiaoyan Liu
Aug 28, 2021·Current Issues in Molecular Biology·Anna ZubrzyckaEwa Brzeziańska-Lasota

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Datasets Mentioned

BETA
GSE5108

Methods Mentioned

BETA
electrophoresis
immunoprecipitation
ChIP
PCR
nuclear translocation
Cesarean

Software Mentioned

GraphPad
GraphPad Prism

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