Targeting autophagy in cardiac ischemia/reperfusion injury: A novel therapeutic strategy

Journal of Cellular Physiology
Mehrdad AghaeiVahid Khori

Abstract

Acute myocardial infarction (AMI) is one of the leading causes of morbidity worldwide. Myocardial reperfusion is known as an effective therapeutic choice against AMI. However, reperfusion of blood flow induces ischemia/reperfusion (I/R) injury through different complex processes including ion accumulation, disruption of mitochondrial membrane potential, the formation of reactive oxygen species, and so forth. One of the processes that gets activated in response to I/R injury is autophagy. Indeed, autophagy acts as a "double-edged sword" in the pathology of myocardial I/R injury and there is a controversy about autophagy being beneficial or detrimental. On the basis of the autophagy effect and regulation on myocardial I/R injury, many studies targeted it as a therapeutic strategy. In this review, we discuss the role of autophagy in I/R injury and its targeting as a therapeutic strategy.

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Citations

Oct 17, 2019·International Journal of Molecular Sciences·Ricardo O S SoaresOrlando Castro-E-Silva
Jul 15, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jinghui YangLiming Wang
Jun 27, 2020·Journal of Cardiovascular Pharmacology·Guixiang ZhaoZhiqiang Liu
Jul 31, 2020·Molecular and Cellular Biochemistry·Fengyue WangLu Fu
Dec 29, 2020·European Journal of Pharmacology·Hamid Reza MoheimaniVahid Khori
Nov 3, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Thawatchai KhuanjingNipon Chattipakorn
Apr 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xingru YangBin Liu

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