Targeting autophagy in liver cancer

Translational Gastroenterology and Hepatology
Pietro Di Fazio, Sami Matrood

Abstract

Autophagy is a catabolic cellular process conserved in animals. It is characterized by the main role of recycling all the non-functional products of the cells. Once, autophagy players detect non-functioning sub-cellular organelles and proteins, they start the so-called nucleation process. The organelles will be surrounded by a double membrane vesicle mainly constituted by endoplasmic reticulum (ER) membrane and autophagy proteins, e.g., MAP1LC3B, Beclin-1, VPS34, Unc-51 like autophagy activating kinase (ULK1) and ubiquitination-related proteins. Then the autophagic membrane will go through an elongation phase involving additional autophagy players. Once the autophagic vesicle is complete, the sub-cellular organelles will be isolated from the rest of the cytosol and driven to the final fusion with lysosomes. Here, the digestion process will end. Alteration and or impairment of autophagy have been shown to be correlated with development of diseases affecting the central nervous system, e.g., Alzheimer and other neurodegenerative diseases. Nonetheless, autophagy defect is responsible for tumorigenesis in blood and solid malignancies, in particular liver cancer. Malignancies of the liver are determined by several genetics and epige...Continue Reading

Citations

Apr 26, 2019·Journal of Cellular Biochemistry·Ziv Radisavljevic
Mar 4, 2020·Cancers·Chandramohan KiruthigaAnupam Bishayee
Dec 20, 2020·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Kegui ZhangXiaohua Yan
Feb 16, 2021·World Journal of Hepatology·Elias KouroumalisDimitrios N Samonakis
Mar 26, 2021·Journal of Biomedical Science·Zhi Xiong ChongWan Yong Ho
Apr 25, 2021·Molecular Biology Reports·Magdelyn Mei-Theng WongSin-Yeang Teow
Dec 24, 2020·Human & Experimental Toxicology·Lining WeiChangjie Huang
Jul 25, 2021·Cancers·Francisco D Rodriguez, Rafael Coveñas
Aug 24, 2021·Journal of Toxicology·Suryakant NitureDeepak Kumar
Nov 3, 2021·Cancer Investigation·Pietro Di FazioKatharina Holzer

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