Targeting autophagy to overcome drug resistance in cancer therapy

Future Medicinal Chemistry
Ankit KumarAnurag Chaudhary

Abstract

Autophagy, a catabolic process, is activated by conditions of stress and nutrient deprivation, which occurs to maintain metabolic homeostasis by performing catabolic lysis of excessive or unnecessary proteins, and injured or aged organelles. Autophagy is regulated by various signaling pathways. Main regulators of autophagy are the PI3K-Akt-mTOR pathway, Beclin1, Bcl-2, Ras and p53. Autophagy plays dual role in cancer, shows both tumor suppressive and oncogenic activity. It is accepted that drug resistance in cancer cells can be overcome by inhibition of autophagy. Herein, we summarize autophagy as a potential target of anticancer drugs and targeting autophagy provides a promising therapeutic strategy to circumvent resistance and enhance the effect of anticancer therapies for cancer patients.

References

Mar 28, 2009·Clinical Science·Wim MartinetGuido R Y De Meyer
May 23, 2009·Journal of Cell Science·Brinda RavikumarDavid C Rubinsztein
Jan 9, 2010·Current Opinion in Cell Biology·Sandra Turcotte, Amato J Giaccia
Jul 20, 2010·Biochimica Et Biophysica Acta·Suning ChenJian Zhang
Mar 24, 2011·Future Medicinal Chemistry·Dan Grandér, Theocharis Panaretakis
Mar 29, 2011·Pharmacology & Therapeutics·Jean M Mulcahy Levy, Andrew Thorburn
Sep 1, 2011·Molecular Cancer Therapeutics·Zhineng J YangFrank A Sinicrope
Jan 21, 2012·Cancer Letters·Yekaterina Y ZaytsevaB Mark Evers
Feb 2, 2012·Journal of Cell Science·Michael Way
Jul 28, 2012·Chinese Journal of Cancer·Bo LiuYan Cheng
May 30, 2013·Trends in Molecular Medicine·Hannelore MaesPatrizia Agostinis
Jun 6, 2013·Future Medicinal Chemistry·Francesca Aredia, A Ivana Scovassi
Jun 19, 2013·Seminars in Cancer Biology·Robin L Macintosh, Kevin M Ryan
Jul 9, 2013·Seminars in Cancer Biology·He LiuHans-Uwe Simon

❮ Previous
Next ❯

Citations

Jun 12, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Myosotys RodriguezMadhavan Nair
Aug 27, 2016·ACS Medicinal Chemistry Letters·Zongxing QiuGuozhi Tang
Feb 15, 2017·ChemMedChem·Zisis V PeitsinisAlexandros E Koumbis
Jul 29, 2017·Nature Reviews. Cancer·Jean M Mulcahy LevyAndrew Thorburn
Nov 4, 2017·Anti-cancer Drugs·Chao ChenXiyun Deng
Sep 22, 2017·Journal of Molecular Endocrinology·Marika H TesselaarTheo S Plantinga
Sep 1, 2018·Molecular Nutrition & Food Research·Yi-Shiou ChiouMin-Hsiung Pan
Jul 19, 2019·Pathology International·Osamu Suzuki
Sep 6, 2019·Journal of Cancer Research and Clinical Oncology·Lin XinChuan Liu
Nov 12, 2019·Journal of Cellular and Molecular Medicine·Yufu TangShuqun Cheng
Nov 9, 2019·Future Medicinal Chemistry·Li-Wen XiaYong-Tao Duan
Feb 26, 2016·Oncotarget·Hao-ran Qian, Yi Yang
Jul 28, 2016·Oncotarget·Yiwei YangJiuhong Kang
Jan 30, 2018·Experimental and Therapeutic Medicine·Xinming DuLeping Li
Jan 9, 2020·Science Advances·Yuping ChenJian Yuan
Jun 1, 2017·International Journal of Oncology·Xiaofei ZhangGong Yang
Oct 6, 2018·Apoptosis : an International Journal on Programmed Cell Death·Xian DuanJun He
Mar 15, 2018·Oncotarget·Jin-Cheng HuangHai Lu
Nov 13, 2018·World Journal of Gastroenterology : WJG·Fang HuangYi-Gang Wang
Mar 6, 2019·Current Topics in Medicinal Chemistry·Vadim V Tarasov TarasovGjumrakch Aliev
May 10, 2020·Bioscience, Biotechnology, and Biochemistry·Yong HeXiong-Zhang Yin
Jan 8, 2020·Cancers·Maria Mrakovcic, Leopold F Fröhlich
Apr 9, 2020·Frontiers in Pharmacology·Jiabei ZhouLushan Yu

❮ Previous
Next ❯

Methods Mentioned

BETA
lipidation
xenograft
transfection

Related Concepts

Related Feeds

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.