Targeting B-cell non Hodgkin lymphoma: New and old tricks

Leukemia Research
Antonio Giovanni SolimandoHermann Einsele

Abstract

The management of B-cell malignancies continues to pose a clinical challenge. In the past years, rituximab (anti-CD20) emerged as the standard of care in the induction treatment of follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL), and mantle cell lymphoma (MCL), as well as in other subsets. Since the benefits of immuno-chemotherapy have been clearly demonstrated in a whole range of lymphomas, several innovative approaches are being explored to achieve significant responses, particularly in refractory B-cell non-Hodgkin lymphoma (NHL) cases. Studies of the comparative effectiveness and structure/function relationship of therapeutic monoclonal antibodies, together with an increased understanding of the molecular features of NHLs, have led to the development of a range of novel therapies, many of which target the tumor in a tailored fashion. Although several molecules can help clinicians to dissect the pathological mechanisms acting in the natural history of the disease, the main purpose of this review emphasize the recent developments in targeting the B-cell NHLs surface. These novel approaches are illustrated, and the new intriguing opportunities offered by bispecific antibodies...Continue Reading

References

Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·M MackP Kufer
Apr 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael HeroldUNKNOWN East German Study Group Hematology and Oncology Study
Feb 5, 2008·Seminars in Immunology·Robert H Carter, Riley Myers
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raanan BergerArnon Nagler
Oct 29, 2008·Hematology/oncology Clinics of North America·Elena M HartmannAndreas Rosenwald
Jul 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephan StilgenbauerUNKNOWN German Chronic Lymphocytic Leukemia Study Group
Oct 3, 2009·Nature Reviews. Rheumatology·Thomas F Tedder
Jun 3, 2010·Cold Spring Harbor Perspectives in Biology·Louis M Staudt
Jan 1, 2009·OncoTargets and Therapy·Dennis A EichenauerHolger Schulz
May 31, 2011·Leukemia & Lymphoma·Yehuda E DeutschJoseph D Rosenblatt
Jan 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andres Forero-TorresKristen N Ganjoo
Apr 27, 2012·Advances in Hematology·Kenneth A FoonPier L Zinzani
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara ProAndrei Shustov
May 25, 2012·The New England Journal of Medicine·David G Maloney
Sep 4, 2012·Pharmacology & Therapeutics·Dirk NagorsenRalf Bargou
May 30, 2013·Haematologica·Elena SabattiniStefano A Pileri
Jul 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gilles A SallesGuillaume Cartron
Jul 31, 2013·Immunity·Daniel S Chen, Ira Mellman
Sep 17, 2013·British Journal of Haematology·Bertrand CoiffierUNKNOWN 415 study investigators
Jan 10, 2014·The New England Journal of Medicine·Valentin GoedeMichael Hallek
May 14, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio SalarGayane Tumyan
Oct 31, 2014·Journal of Hematology & Oncology·Tejas SureshStefan K Barta
Feb 28, 2015·Blood·Kristie A Blum
Apr 9, 2015·Frontiers in Physiology·Kyle A BeckwithNatarajan Muthusamy

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Citations

Jun 2, 2016·Clinical and Experimental Pharmacology & Physiology·Huiying QiuLei Chen
Aug 18, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marianne Engelhard
Feb 8, 2018·Frontiers in Immunology·Thais BascuasJosé A Chabalgoity
Oct 3, 2019·Cancers·Theodoulakis ChristofiApostolos Zaravinos
May 3, 2020·International Journal of Molecular Sciences·Antonio G SolimandoVito Racanelli
May 28, 2020·Frontiers in Immunology·Margaux LejeuneJo Caers
Jul 16, 2020·Cancers·Antonio Giovanni SolimandoDomenico Ribatti
Aug 1, 2020·Pharmaceutics·Maria Valeria GiuliMaria Carafa
Nov 11, 2020·International Journal of Molecular Sciences·Negar HosseinkhaniBehzad Baradaran
Mar 3, 2020·Translational Oncology·Tiziana AnneseDomenico Ribatti
Apr 6, 2021·Frontiers in Oncology·Liwei Lv, Yuanbo Liu

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