Jul 16, 2011

Targeting B lymphoma with nanoparticles bearing glycan ligands of CD22

Leukemia & Lymphoma
Weihsu C ChenJames C Paulson

Abstract

CD22 is a member of the siglec (sialic acid-binding immunoglobulin-like lectin) family expressed on B cells that recognizes glycans of glycoproteins as ligands. Because siglecs exhibit restricted expression on one or a few leukocyte cell types, they have gained attention as attractive targets for cell-directed therapies. Several antibody-based therapies targeting CD22 (Siglec-2) are currently in clinical trials for the treatment of hairy cell leukemia and other B cell lymphomas. As an alternative to antibodies we have developed liposomal nanoparticles decorated with glycan ligands of CD22 that selectively target B cells. Because CD22 is an endocytic receptor, ligand-decorated liposomes are bound by CD22 and rapidly internalized by the cell. When loaded with a toxic cargo such as doxorubicin, they are efficacious in prolonging life in a Daudi B cell lymphoma model. These B cell targeted nanoparticles have been demonstrated to bind and kill malignant B cells from patients with hairy cell leukemia, marginal zone lymphoma and chronic lymphocytic leukemia. The results demonstrate the potential of using CD22 ligand-targeted liposomal nanoparticles as an alternative approach for the treatment of B cell malignancies.

  • References7
  • Citations18

Citations

Mentioned in this Paper

Doxorubicin
Antineoplastic Agents
CD22 antigen
Immunoglobulin Activity
Glycoproteins
Sialic Acid Assay
Hairy Cell Leukemia
Immunoglobulins
B-Lymphocytes
Leukocytes

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