Targeting bacterial biofilms via surface engineering of gold nanoparticles

RSC Advances
Karuna GiriY S Prakash

Abstract

Bacterial biofilms are associated with persistent infections that are resistant to conventional antibiotics and substantially complicate patient care. Surface engineered nanoparticles represent a novel, unconventional approach for disruption of biofilms and targeting of bacterial pathogens. Herein, we describe the role of surface charge of gold nanoparticles (AuNPs) on biofilm disruption and bactericidal activity towards Staphylococcus aureus and Pseudomonas aeruginosa which are important ventilator associated pneumonia (VAP) pathogens. In addition, we study the toxicity of charged AuNPs on human bronchial epithelial cells. While 100% positively charged AuNP surface was uniformly toxic to both bacteria and epithelial cells, reducing the extent of positive charge on the AuNP surface at moderate concentrations prevented epithelial cell toxicity. Reducing surface charge was however also less effective in killing bacteria. Conversely, increasing AuNP concentration while maintaining a low level of positivity continued to be bactericidal and disrupt the bacterial biofilm and was less cytotoxic to epithelial cells. These initial in vitro studies suggest that modulation of AuNP surface charge could be used to balance effects on bacteri...Continue Reading

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Mar 24, 2016·F1000Research·Akash GuptaVincent M Rotello
Nov 23, 2016·BioMed Research International·Mohankandhasamy Ramasamy, Jintae Lee
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Oct 22, 2020·International Journal of Molecular Sciences·Abhayraj S JoshiIvan Mijakovic

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