Targeting BCL-2 regulated apoptosis in cancer

Open Biology
Kirsteen J Campbell, Stephen W G Tait

Abstract

The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death during development and maintains organismal health. When unbalanced, the BCL-2 family can act as a barrier to apoptosis and facilitate tumour development and resistance to cancer therapy. Here we discuss the BCL-2 family, their deregulation in cancer and recent pharmaceutical developments to target specific members of this family as cancer therapy.

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Jun 18, 2019·Journal of Immunoassay & Immunochemistry·Morvarid Asadipour, Zahra Amirghofran
May 19, 2019·The EMBO Journal·Joel S Riley, Stephen Wg Tait
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Datasets Mentioned

BETA
ABT737

Methods Mentioned

BETA
gene knockout
xenograft
xenografts

Clinical Trials Mentioned

ISRCTN98335443
NCT02992483
NCT02979366
NCT02675452

Software Mentioned

cBioportal

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

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