Targeting Breast Cancer Stem Cells: A Methodological Perspective

Current Stem Cell Research & Therapy
Marco A Velasco-VelázquezSonia M Pérez-Tapia

Abstract

Cancer Stem Cells (CSCs) constitute a subpopulation at the top of the tumor cell hierarchy that contributes to tumor heterogeneity and is uniquely capable of seeding new tumors. Because of their biological properties, CSCs have been pointed out as therapeutic targets for the development of new therapies against breast cancer. The identification of drugs that selectively target breast CSCs requires a clear understanding of their biological functions and the experimental methods to evaluate such hallmarks. Herein, we review the methods to study breast CSCs properties and discuss their value in the preclinical evaluation of CSC-targeting drugs.

References

Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
May 21, 2003·Genes & Development·Gabriela DontuMax S Wicha
Sep 21, 2004·Oncogene·Muhammad Al-Hajj, Michael F Clarke
Nov 13, 2004·Breast Cancer Research : BCR·Gabriela DontuMax S Wicha
Apr 2, 2005·Nature Reviews. Cancer·Michael DeanSusan Bates
May 12, 2005·Journal of Mammary Gland Biology and Neoplasia·Gabriela Dontu, Max S Wicha
Oct 17, 2006·Molecular Cancer Therapeutics·Beverly A Teicher
Jan 2, 2007·Current Biology : CB·Virginie ClementAriel Ruiz i Altaba
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·I ZucchiR Dulbecco
May 31, 2008·Nature Reviews. Cancer·Michael BaumannRichard Hill
Jul 10, 2008·Expert Opinion on Drug Metabolism & Toxicology·Satori A MarchittiVasilis Vasiliou
Oct 30, 2008·Journal of the National Cancer Institute·Melinda G Hollingshead
Dec 17, 2008·Current Stem Cell Research & Therapy·Jan S Moreb
Jan 6, 2009·Nature Biotechnology·Tamra E Werbowetski-OgilvieMickie Bhatia
Jul 8, 2009·Methods in Molecular Biology·Aniruddha J DeshpandeChristian Buske
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chad J CreightonJenny C Chang
Nov 13, 2009·Breast Cancer Research : BCR·Matthew J MeyerBarbara K Vonderhaar
May 28, 2010·Stem Cells·Gangadharan B SajithlalEdward V Prochownik
Jul 6, 2010·Molecular Oncology·Sean P McDermott, Max S Wicha
Aug 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Joseph H TaubeSendurai A Mani
Aug 27, 2010·The Journal of Investigative Dermatology·Jim B BoonyaratanakornkitRuby Ghadially
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Huiping LiuMichael F Clarke
Jun 7, 2011·The American Journal of Pathology·Marco A Velasco-VelázquezRichard G Pestell
Sep 3, 2011·Breast Cancer Research : BCR·Deborah L Holliday, Valerie Speirs
Nov 29, 2011·Breast Cancer Research and Treatment·Mohamed A H AhmedIan O Ellis
Jan 18, 2012·The International Journal of Biochemistry & Cell Biology·Marco A Velasco-VelázquezRichard G Pestell
May 12, 2012·Nature Reviews. Cancer·Thomas Brabletz

❮ Previous
Next ❯

Citations

Jun 22, 2021·Frontiers in Cell and Developmental Biology·Amrutha MohanTessy Thomas Maliekal
Aug 10, 2021·World Journal of Stem Cells·Nohemí Salinas-JazmínMarco Velasco-Velázquez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.