Targeting breast cancer through its microenvironment: current status of preclinical and clinical research in finding relevant targets

Pharmacology & Therapeutics
H H NienhuisC P Schröder

Abstract

It is increasingly evident that not only breast cancer cells, but also the tissue embedding these cells: the tumor microenvironment, plays an important role in tumor progression, metastasis formation and treatment sensitivity. This review focuses on the current knowledge of processes by which the microenvironment affects breast cancer, including formation of the metastatic niche, metabolic stimulation, stimulation of tumor cell migration, immune modulation, angiogenesis and matrix remodeling. The number of drugs targeting key factors in these processes is expanding, and the available clinical data is increasing. Therefore current strategies for intervention and prediction of treatment response are outlined. At present, targeting the formation of the metastatic niche and metabolic stimulation by the breast cancer microenvironment, are already showing clinical efficacy. Intervening in the stimulation of tumor cell migration and immune modulation by the microenvironment upcoming fields of great research interest. In contrast, targeting microenvironmental angiogenesis or matrix remodeling appears to be of limited clinical relevance in breast cancer treatment so far. Further research is warranted to optimize intervention strategies ...Continue Reading

References

May 1, 1991·Breast Cancer Research and Treatment·M A Chaudary
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M PugeatJ Tourniaire
Sep 1, 1988·The Journal of Clinical Endocrinology and Metabolism·S R PlymateK E Friedl
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S JainR D Rubens
Mar 22, 1996·Science·D R LeachJ P Allison
Aug 6, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L TrusolinoC Boccaccio
Sep 21, 2000·American Journal of Epidemiology·P A van den BrandtD J Hunter
Mar 21, 2001·The Journal of Experimental Medicine·E Y LinJ W Pollard
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·E V JensenJ A Gustafsson
Mar 30, 2002·Science·Lisa M CoussensLynn M Matrisian
May 11, 2002·Science·Bryony S Wiseman, Zena Werb
May 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takahiro HasebeAtsushi Ochiai
Sep 5, 2002·Nature Reviews. Cancer·Christopher Mark Overall, Carlos López-Otín
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoshiko IwaiNagahiro Minato
Apr 25, 2003·The New England Journal of Medicine·Eugenia E CalleMichael J Thun
Aug 21, 2003·Journal of the National Cancer Institute·T J KeyUNKNOWN Endogenous Hormones Breast Cancer Collaborative Group
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·E R Simpson
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
May 12, 2004·Nature Reviews. Drug Discovery·Napoleone FerraraWilliam Novotny
Jul 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Yasir H Ibrahim, Douglas Yee
Sep 18, 2004·The Journal of Pathology·Paolo ViacavaGeneroso Bevilacqua
Nov 16, 2004·Cancer Cell·Yan M LiMien-Chie Hung
Nov 19, 2004·Nature·Neil A BhowmickHarold L Moses
Mar 16, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shyr-Ming Sheen-ChenFong-Fu Chou
May 26, 2005·JAMA : the Journal of the American Medical Association·Michelle D HolmesGraham A Colditz
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yibin KangJoan Massagué
Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea EisenSteven A Narod
May 2, 2006·Molecular Cancer Therapeutics·Daniel H AlbertSteven K Davidsen
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hannah M LindenDavid A Mankoff
May 19, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bhuvaneswari RamaswamyCharles L Shapiro
Sep 12, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Amalia MilanoFatima Cardoso
Nov 23, 2006·Cancer Research·Elaine Y LinJeffrey W Pollard
Mar 3, 2007·Cancer Research·Piyush B GuptaCharlotte Kuperwasser
Mar 31, 2007·Nature Reviews. Drug Discovery·Judah Folkman
Apr 25, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Giuseppe PandiniLiliane Goetsch
Apr 25, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·D L FarringtonC A Ray

❮ Previous
Next ❯

Citations

Dec 1, 2015·ACS Medicinal Chemistry Letters·Andrijana MeščićSilvana Raić-Malić
Jan 21, 2017·Journal of Cellular Biochemistry·Muhammad TariqBo Yang
Apr 22, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Mary C RegierDavid J Beebe
Feb 13, 2016·Advanced Healthcare Materials·Yongfeng ZhaoYongjian Liu
Oct 13, 2019·The Journal of Pathology. Clinical Research·Hilde Ytre-Hauge SmelandLars A Akslen
Mar 18, 2020·Journal of Clinical Medicine·Patricia Fernández-NogueiraNeus Carbó
Oct 24, 2019·Anti-cancer Agents in Medicinal Chemistry·Sivakumar P MalliappanAbimanyu Sugumaran

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.