Targeting Cancer Cells using 3-bromopyruvate for Selective Cancer Treatment

Saudi Journal of Medicine & Medical Sciences
Hussam H Baghdadi

Abstract

Cancer treatment deserves more research efforts despite intensive conventional treatment modalities for many types of malignancies. Metastasis and resistance to chemotherapy and radiotherapy receive a lot of global research efforts. The current advances in cancer biology may improve targeting the critical metabolic differences that distinguish cancer cells from normal cells. Cancer cells are highly glycolytic for energy production, exhibit the Warburg effect, establish aggressive acidic microenvironment, maintain cancer stem cells, exhibit resistance to chemotherapy, have low antioxidant systems but different ΔΨm (delta psi, mitochondrial transmembrane potential), express P-glycoprotein for multidrug resistance, upregulate glucose transporters and monocarboxylate transporters and are under high steady-state reactive oxygen species conditions. Normal cells differ in all these aspects. Lactate produced through the Warburg effect helps cancer metastasis. Targeting glycolysis reactions for energy production in cancer cells seems promising in decreasing the proliferation and metastasis of cancer cells. 3-bromopyruvate makes use of cancer biology in treating cancer cells, cancer stem cells and preventing metastasis in human cancer as...Continue Reading

References

Oct 2, 2013·Bioscience Reports·Nívea Dias AmoêdoFranklin David Rumjanek

❮ Previous
Next ❯

Citations

Mar 22, 2020·Journal of Biochemical and Molecular Toxicology·Mohammed A MansourAfrah F Salama
Jan 16, 2021·International Journal of Molecular Sciences·Natalia PieńkowskaIzabela Sadowska-Bartosz
Feb 27, 2021·Frontiers in Cell and Developmental Biology·Peter W HalcrowXuesong Chen
Nov 28, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Gabriela L OliveiraPaulo J Oliveira
Aug 31, 2021·International Journal of Cancer. Journal International Du Cancer·Daichi MoriTsunao Kishida

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft

Related Concepts

Related Feeds

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.