Targeting cancer gene therapy with magnetic nanoparticles.

Oncotarget
Charles LiAndrew C Keates

Abstract

Recent advances in cancer genomics have opened up unlimited potential for treating cancer by directly targeting culprit genes. However, novel delivery methods are needed in order for this potential to be translated into clinically viable treatments for patients. Magnetic nanoparticle technology offers the potential to achieve selective and efficient delivery of therapeutic genes by using external magnetic fields, and also allows simultaneous imaging to monitor the delivery in vivo. Compared to conventional gene delivery strategies, this technique has been shown to significantly increase gene delivery to human xenograft tumors models, as well as various internal organs (e.g. liver, kidney) and the central nervous system. Magnetic nanoparticle technology, therefore, has the potential to turn the challenge of gene therapy in vivo into a new frontier for cancer treatment.

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Citations

Mar 26, 2013·Advanced Healthcare Materials·Gil GonçalvesPaula Alexandrina A P Marques
Nov 13, 2013·Cancers·Elisa PanzariniLuciana Dini
Dec 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Federico D'AgataCaterina Guiot
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Jun 13, 2014·Molecular Pharmaceutics·Elisa Panzarini, Luciana Dini

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Methods Mentioned

BETA
xenograft
xenografts
transfection

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