Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors

Drug Discovery Today
Shao-Lin ZhangKin Yip Tam

Abstract

Cancer cells feature a switch in glucose metabolism from oxidative phosphorylation to cytoplasm-based glycolysis. This altered cellular metabolic pathway meets the survival and proliferation needs for tumor progression. Targeting the metabolic remodeling could offer opportunities for developing effective anticancer therapeutics. Human lactate dehydrogenase (hLDH)5 plays a crucial part in the promotion of glycolysis and is overexpressed in various human tumors, and thus could be a potential anticancer drug target. Here, we briefly discuss the roles of hLDH5 and its connections with cancer metabolism. Then, we review the reported small molecules in light of their binding modes to hLDH5. Finally, possible directions for future development of hLDH5 inhibitors are proposed. We hope that this review will provoke interest in developing hLDH5 inhibitors.

Citations

Apr 19, 2019·Journal of Cellular Biochemistry·Jinfeng FengYi Chen
Mar 12, 2020·Oncoimmunology·Sandra Van WilpeNiven Mehra
Feb 18, 2020·Future Medicinal Chemistry·Mark R WoodfordMehdi Mollapour
Jan 31, 2021·Journal of Personalized Medicine·Maria Dolores Moya-GarzonMonica Diaz-Gavilan
Apr 8, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xianjiu LiaoYizhong Shen
Jul 30, 2021·Drug Discovery Today·Zi-Xian LiaoPan-Chyr Yang
Oct 5, 2021·Human Cell·Xingchen WangXiuzhen Han
Dec 5, 2021·Nature Reviews. Drug Discovery·Zachary E StineChi V Dang

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