Targeting cancer stem cells as therapeutic approach in the treatment of colorectal cancer

The International Journal of Biochemistry & Cell Biology
Seyed Mostafa ParizadehAmir Avan

Abstract

Colorectal cancer is one of the most common cancers globally. A large portion of colorectal cancer patients who are treated with conventional chemotherapy eventually develop local recurrence or metastases. The failure of a complete cure in colorectal cancer patients may be related to the lack of complete eradication of cancer stem cells when using conventional therapy. Colorectal cancer stem cells comprise a small population of tumor cells that possess the properties of rapid proliferation and differentiation. The colorectal cancer stem cells are also phenotypically and molecularly distinct, and resistant to conventional chemo-radiotherapy. Therefore, it is important to identify approaches in combination with conventional therapy for targeting and eradicating cancer cells. The aim of this review was to summarize the main findings of recent studies on targeting colorectal cancer stem cells as a novel therapeutic approach in colorectal cancer treatment.

Citations

Jul 14, 2019·BMC Complementary and Alternative Medicine·Lijuan WeiBaichun Liu
Aug 21, 2020·BMC Cancer·Selma ZargariMohammad Mahdi Forghanifard
Jul 7, 2020·Frontiers in Cell and Developmental Biology·Diana PáduaPatrícia Mesquita
Jun 27, 2019·Current Drug Targets·Seyed Mostafa ParizadehAmir Avan
Aug 25, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Seyed Mohammad HosseiniFarhad Jadidi-Niaragh
Feb 11, 2021·International Journal of Molecular Sciences·Ga-Ram HwangJingfang Ju
Apr 10, 2021·Journal of Pharmacopuncture·Zahra AhmadiMilad Ashrafizadeh

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