Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context

Biochimica Et Biophysica Acta. Reviews on Cancer
Junfeng BiPaul S Mischel

Abstract

Tumors cells reprogram their metabolism to fuel rapid growth. The ability to trace nutrient fluxes in the context of specific alterations has provided new mechanistic insight into the process of oncogenic transformation. A broad array of complementary genetic, epigenetic, transcriptional and translational mechanisms has been identified, revealing a metabolic landscape of cancer. However, cancer metabolism is not a static or uniform process, including within a single tumor. Tumor cells adapt to changing environmental conditions, profoundly shaping the enzymatic dependencies of individual cells. The underlying molecular mechanisms of adaptation, and the specific interactions between tumor genotype, oncogenic signaling, and tissue/biochemical context, remain incompletely understood. In this review, we examine dynamic aspects of how metabolic dependencies develop in cancer, shaped both by genotype and biochemical environment, and review how these interlaced processes generate targetable metabolic vulnerabilities. This article is part of a Special Issue entitled: Cancer Metabolism edited by Dr. Chi Van Dang.

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Citations

Dec 4, 2019·Current Opinion in Pediatrics·Sameer H Issaq, Christine M Heske
Mar 28, 2019·Nature Reviews. Clinical Oncology·Xiaoyun LiPing-Chih Ho
Feb 20, 2021·Journal of Clinical and Translational Hepatology·Jie WangJin Yang
May 1, 2021·Experimental Hematology & Oncology·Chao Wang, Daya Luo
Jun 30, 2021·Trends in Cancer·Lin XiaoKlaartje Somers

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