Targeting caveolin-3 for the treatment of diabetic cardiomyopathy

Pharmacology & Therapeutics
Lucy MurfittAshraf Kitmitto

Abstract

Diabetes is a global health problem with more than 550 million people predicted to be diabetic by 2030. A major complication of diabetes is cardiovascular disease, which accounts for over two-thirds of mortality and morbidity in diabetic patients. This increased risk has led to the definition of a diabetic cardiomyopathy phenotype characterised by early left ventricular dysfunction with normal ejection fraction. Here we review the aetiology of diabetic cardiomyopathy and explore the involvement of the protein caveolin-3 (Cav3). Cav3 forms part of a complex mechanism regulating insulin signalling and glucose uptake, processes that are impaired in diabetes. Further, Cav3 is key for stabilisation and trafficking of cardiac ion channels to the plasma membrane and so contributes to the cardiac action potential shape and duration. In addition, Cav3 has direct and indirect interactions with proteins involved in excitation-contraction coupling and so has the potential to influence cardiac contractility. Significantly, both impaired contractility and rhythm disturbances are hallmarks of diabetic cardiomyopathy. We review here how changes to Cav3 expression levels and altered relationships with interacting partners may be contributory fa...Continue Reading

References

Jun 1, 1992·The Journal of Clinical Investigation·P NuutilaU Wegelius
Feb 21, 1992·Cell·K G RothbergR G Anderson
Jan 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·A DoriaG Crepaldi
Apr 1, 1987·The Journal of Clinical Endocrinology and Metabolism·J K KahnA I Vinik
Nov 8, 1972·The American Journal of Cardiology·S RublerA Grishman
Jul 1, 1974·The American Journal of Cardiology·W B KannelW P Castelli
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·M MurataK Simons
Jun 1, 1995·The Journal of Cell Biology·C C MastickA R Saltiel
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·A M FraR G Parton
Jan 1, 1995·Annual Review of Medicine·M Brownlee
May 1, 1995·Journal of the American College of Cardiology·V Di BelloO Giampietro
Dec 1, 1994·The Journal of Cell Biology·P E SchererH F Lodish
Aug 4, 1994·Biochimica Et Biophysica Acta·G D LopaschukB O Schönekess
May 20, 1993·The New England Journal of Medicine·M J StampferW C Willett
May 20, 1993·The New England Journal of Medicine·E B RimmW C Willett
Jan 2, 1996·FEBS Letters·M Way, R G Parton
Nov 1, 1996·The Journal of Biological Chemistry·G García-CardeñaW C Sessa
Jan 13, 1997·The Journal of Cell Biology·R G PartonE Stang
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·C J FieldingP E Fielding
Jul 1, 1997·Trends in Biochemical Sciences·B VanhaesebroeckM D Waterfield
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·H WakasakiG L King
Mar 7, 1998·The Journal of Biological Chemistry·O FeronT Michel
Oct 3, 1998·The Journal of Biological Chemistry·M YamamotoY Ishikawa
Oct 13, 1998·Journal of the American College of Cardiology·H DrexlerG Hasenfuss
Jan 23, 1999·The Journal of Clinical Investigation·A DresnerG I Shulman

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Citations

Apr 30, 2020·American Journal of Physiology. Cell Physiology·Jake S RussellJohn P Headrick
May 5, 2017·Frontiers in Pharmacology·David A MacDougallSarah Calaghan
Sep 19, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kai ZhangLanfang Li

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