Targeting CD14 on blood derived cells improves intracortical microelectrode performance

Biomaterials
Hillary W BedellJeffrey R Capadona

Abstract

Intracortical microelectrodes afford researchers an effective tool to precisely monitor neural spiking activity. Additionally, intracortical microelectrodes have the ability to return function to individuals with paralysis as part of a brain computer interface. Unfortunately, the neural signals recorded by these electrodes degrade over time. Many strategies which target the biological and/or materials mediating failure modes of this decline of function are currently under investigation. The goal of this study is to identify a precise cellular target for future intervention to sustain chronic intracortical microelectrode performance. Previous work from our lab has indicated that the Cluster of Differentiation 14/Toll-like receptor pathway (CD14/TLR) is a viable target to improve chronic laminar, silicon intracortical microelectrode recordings. Here, we use a mouse bone marrow chimera model to selectively knockout CD14, an innate immune receptor, from either brain resident microglia or blood-derived macrophages, in order to understand the most effective targets for future therapeutic options. Using single-unit recordings we demonstrate that inhibiting CD14 from the blood-derived macrophages improves recording quality over the 16 ...Continue Reading

Citations

Aug 22, 2018·Journal of Neural Engineering·L Nathan PerkinsTimothy J Gardner
Aug 31, 2018·Frontiers in Bioengineering and Biotechnology·John K HermannJeffrey R Capadona
Nov 15, 2018·Micromachines·Bailey M WinterErin K Purcell
Feb 26, 2019·Nature Materials·Xiao YangCharles M Lieber
May 28, 2020·Frontiers in Bioengineering and Biotechnology·Shreya MahajanEvon S Ereifej
Nov 15, 2018·Micromachines·Takashi D Y Kozai
Aug 6, 2019·Frontiers in Neuroscience·R Dixon DorandAlex Y Huang
Nov 15, 2018·Micromachines·Andrew Campbell, Chengyuan Wu
Jan 22, 2019·Journal of Neuroscience Methods·Sydney C LindnerAndrew J Shoffstall
Feb 24, 2021·Journal of Neural Engineering·Mitchell DubaniewiczTakashi D Y Kozai
Jun 25, 2021·International Immunopharmacology·Jiawei ZhangJianliang Fu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.