Targeting Cell Senescence for the Treatment of Age-Related Bone Loss

Current Osteoporosis Reports
Robert J PignoloAbhishek Chandra

Abstract

We review cell senescence in the context of age-related bone loss by broadly discussing aging mechanisms in bone, currently known inducers and markers of senescence, the senescence-associated secretory phenotype (SASP), and the emerging roles of senescence in bone homeostasis and pathology. Cellular senescence is a state of irreversible cell cycle arrest induced by insults or stressors including telomere attrition, oxidative stress, DNA damage, oncogene activation, and other intrinsic or extrinsic triggers and there is mounting evidence for the role of senescence in aging bone. Cellular aging also instigates a SASP that exerts detrimental paracrine and likely systemic effects. With aging, multiple cell types in the bone microenvironment become senescent, with osteocytes and myeloid cells as primary contributors to the SASP. Targeting undesired senescent cells may be a favorable strategy to promote bone anabolic and anti-resorptive functions in aging bone, with the possibility of improving bone quality and function with normal aging and/or disease.

References

Dec 1, 1978·Mechanisms of Ageing and Development·P M Bemiller, L H Lee
Jan 1, 1991·Experimental Gerontology·G M Kiebzak
Mar 1, 1990·The Journal of Clinical Investigation·I R GarrettG R Mundy
Jun 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M KawaseT Matsuo
Jun 1, 1988·Annals of Internal Medicine·G P DalskyS J Birge
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R K MoyzisJ R Wu
Mar 9, 1968·Lancet·P D Saville
Apr 1, 1972·Journal of Ultrastructure Research·J Lipetz, V J Cristofalo
Aug 1, 1984·Mechanisms of Ageing and Development·W De PriesterD L Knook
Jan 1, 1981·Mechanisms of Ageing and Development·T Mets, G Verdonk
Apr 1, 1980·Acta Orthopaedica Scandinavica·H KristenssonB E Nilsson
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Nov 1, 1994·Molecular and Cellular Biology·V MarechalA J Levine
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Jan 1, 1994·The American Journal of Medicine·E A Krall, B Dawson-Hughes
Jan 1, 1996·The Journal of Clinical Investigation·C SlemendaC C Johnston
Aug 1, 1995·Bone·C C Johnston, C W Slemenda
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·D A AlcortaJ C Barrett
Jan 7, 1998·Experimental Cell Research·M Serrano
Oct 9, 1998·Genes & Development·J ZhuJ M Bishop
Mar 25, 2000·Molecular and Cellular Biology·M MalumbresA Pellicer
Jul 24, 2001·JAMA : the Journal of the American Medical Association·A D PradhanP M Ridker
Aug 4, 2001·Archives of Internal Medicine·E Karcic, A A Karcic
Aug 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K YudohT Kimura
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Akinori SakaiToshitaka Nakamura
Apr 3, 2003·EMBO Reports·Mikhail V Blagosklonny
Apr 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stan GronthosSongtao Shi
May 6, 2003·The Journal of Biological Chemistry·Kyung A ChoSang Chul Park
Jun 6, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Maria A Yialamas, Frances J Hayes
Dec 1, 1961·Experimental Cell Research·L HAYFLICK, P S MOORHEAD
Mar 1, 1965·Experimental Cell Research·L HAYFLICK
Oct 1, 2003·Experimental and Molecular Pathology·Hiroshi IchiyoshiAiro Tsubura
Nov 11, 2003·Nature·Fabrizio d'Adda di FagagnaStephen P Jackson
Jan 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Yiping WuDerek Le Roith
Feb 7, 2004·Archives of Gerontology and Geriatrics·Douglas L Schmucker, Howard Sachs

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Citations

Sep 12, 2019·Annual Review of Medicine·Cheng ChengDolores M Shoback
Jul 6, 2020·Stem Cell Research & Therapy·Liqiang ZhangWenjia Liu
Feb 26, 2021·Mechanisms of Ageing and Development·Dhara PatelSadanand Fulzele
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Jingyi CaiZhihe Zhao
Apr 20, 2021·JBMR Plus·Robert J PignoloAbhishek Chandra
Sep 12, 2021·Bone Research·Mei WanJennifer H Elisseeff

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