Targeting chemotherapy for malignant brain tumor using thermosensitive liposome and localized hyperthermia

Journal of Neurosurgery
K KakinumaM Kuroki

Abstract

Thermosensitive liposomes are microscopic vesicles that can contain drugs and release them effectively in response to hyperthermia. To deliver an antitumor drug specifically to brain tumor, the authors used thermosensitive liposomes containing cis-diamminedichloroplatinum (CDDP) in conjunction with localized brain heating. The authors then investigated the antitumor effect on rat malignant glioma. Rous sarcoma virus-induced malignant glioma cells were transplanted into the brains of Fisher rats. Ten days after tumor inoculation, the rats were assigned to one of six treatment groups: control, free CDDP, hyperthermia, free CDDP + hyperthermia, liposomes containing CDDP (CDDP-liposome), and CDDP-liposome + hyperthermia. Liposomes containing CDDP or free CDDP were injected via the tail vein. Brain tumor heating was administered by means of a radiofrequency antenna designed at our institute. The rats treated with CDDP-liposome + hyperthermia had the longest survival time and the tumor CDDP level of this group was the highest when compared to the other groups. Histopathological examination showed that tumor cells were necrotized but surrounding normal brain tissue remained undamaged. On the basis of these findings we suggest that the...Continue Reading

References

Jan 1, 1978·Annual Review of Biophysics and Bioengineering·R E Pagano, J N Weinstein
Sep 2, 1975·Biochimica Et Biophysica Acta·M M JonahY E Rahman
Jul 1, 1992·Pharmacology & Toxicology·W M Pardridge
Feb 20, 1992·Biochimica Et Biophysica Acta·M J MicklusS I Rapoport
Jan 1, 1992·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M WatanabeM Kuroki
Jun 24, 1991·Journal of Immunological Methods·C R Alving
Sep 30, 1991·Biochimica Et Biophysica Acta·T M Allen, C Hansen
Jun 30, 1988·Biochemical and Biophysical Research Communications·F Umezawa, Y Eto
Jan 1, 1986·Journal of Neurosurgery·K TakakuraH Mogami
Aug 1, 1985·The Journal of Cell Biology·J Connor, L Huang
Jan 1, 1984·Neurosurgical Review·Y UshioN Arita
Dec 1, 1982·Cancer Chemotherapy and Pharmacology·D J StewartT L Loo
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H SchneiderC R Hackenbrock
Dec 23, 1981·Biochimica Et Biophysica Acta·R M Abra, C A Hunt
Jul 26, 1995·Biochemical and Biophysical Research Communications·H OdaA Kakinuma

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Citations

Aug 26, 1999·Ultrasound in Medicine & Biology·C J Diederich, K Hynynen
Oct 28, 1998·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·A SaitoK Kakinuma
Dec 2, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Grace H HuynhFrancis C Szoka
Jul 20, 2011·Biochimica Et Biophysica Acta·Richard T FrankJoseph Najbauer
Sep 17, 2004·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·H AokiR Tanaka
Dec 19, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Meritxell Teixidó, Ernest Giralt
Jun 12, 1999·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S TakahashiH Takahashi
Aug 7, 2020·Journal of Neuro-oncology·David H ShinAshley P Ghiaseddin
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lars H LindnerMarc Dellian
Dec 19, 2006·Molecular Cancer Therapeutics·A B MadhankumarJames R Connor
Sep 29, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Cristina Prieto, Isabel Linares

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