Targeting chronic inflammation in cerebral aneurysms: focusing on NF-kappaB as a putative target of medical therapy

Expert Opinion on Therapeutic Targets
Tomohiro Aoki, M Nishimura

Abstract

Cerebral aneurysms (CAs) are the main cause of life-threatening subarachnoid hemorrhage. Given its prevalence and endpoint, CA treatment is a public health issue. Effective medical treatment of CAs is lacking because the detailed mechanisms of CA formation are incompletely understood. The aim of this contribution is to review recent articles about CA formation, to suggest the underlying mechanisms of CA formation, and to discuss potential therapeutic targets for treatment. Articles were collected by an internet search of PubMed using the keywords 'intracranial' or 'cerebral aneurysm'. A review of articles about the pathogenesis of CA formation focusing on inflammation. Recent articles demonstrate that inflammation-related-molecule induction and inflammatory cell infiltration in CA walls and the close relationship between inflammatory responses and CA formation. From studies in experimental models, chronic inflammation triggered primarily by NF-kappaB activation in endothelial cells and subsequent macrophage infiltration have critical roles in CA formation. Inhibition of inflammation-related molecules in CA walls results in the decreased incidence of CA formation. Agents with anti-inflammatory activity (particularly anti- NF-kap...Continue Reading

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Citations

May 17, 2013·Genetic Testing and Molecular Biomarkers·Xiutian SimaChao You
Jan 22, 2011·Journal of Biomedicine & Biotechnology·Tomohiro Aoki, Masaki Nishimura
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Dec 18, 2018·Neurologia Medico-chirurgica·Haruka MiyataTomohiro Aoki
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Sep 11, 2018·Neurointervention·Keun-Hwa Jung
Mar 9, 2021·Journal of Drug Targeting·Zhixian JiangJinning Zhang

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