Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration

Cell Death & Disease
Jia-Jian WangBiao Yan

Abstract

Glaucoma is a neurodegenerative disease characterized by retinal ganglion cell (RGC) loss, optic disc excavation, and progressive visual field loss. Direct or indirect ameliorating retinal neurodegeneration is a promising therapeutic therapy for glaucoma. Circular RNAs (circRNAs) are a class of covalently closed circular RNA transcripts and have emerged as potential regulators in several neurodegenerative diseases. In this study, we show that cZRANB1 expression is significantly upregulated in retinal neurodegeneration induced by glaucoma. cZRANB1 knockdown decreases retinal reactive gliosis, glial cell activation, and facilitates RGC survival in vivo. cZRANB1 knockdown directly regulates Müller cell function and indirectly regulates RGC function in vitro. cZRANB1 acts as miRNA sponge to regulate Müller cell function through cZRANB1/miR-217/RUNX2 network. Intervention of cZRANB1 expression would become an effective strategy for treating retinal neurodegeneration.

References

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Citations

Nov 18, 2018·Canadian Journal of Physiology and Pharmacology·Akash K GeorgeMahavir Singh
Jun 11, 2020·Clinical & Experimental Ophthalmology·Lan-Fang SunZi-Bing Jin
Sep 17, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Hamidreza MoazzeniElahe Elahi
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Chengshou ZhangYibo Yu
Sep 1, 2020·Current Eye Research·Miao HeWei Wang
Jan 24, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Qiwei YangBurton B Yang
Apr 6, 2021·Molecular Therapy. Nucleic Acids·Juhyun Song, Young-Kook Kim
Nov 6, 2021·Advanced Biology·Lan-Fang SunZi-Bing Jin

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Methods Mentioned

BETA
transfection
pull-down

Software Mentioned

TargetScan
miRana

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