Targeting cytokines beyond tumor necrosis factor-alpha and interleukin-1 in rheumatoid arthritis

Current Rheumatology Reports
Iain B McInnes, J Alastair Gracie

Abstract

Targeting tumor necrosis factor-a has proven of considerable value in treatment for rheumatoid arthritis, with substantial benefits achieved in a proportion of treated patients. However, a significant number of patients do not achieve sufficient improvement and as a result there remains considerable unmet clinical need. A number of cytokines have recently been described with proinflammatory activity in rheumatoid arthritis synovitis, including interleukin (IL) -6, IL-12, IL-15, and IL-18. We review recent data that support the notion that some or all of these moieties offer therapeutic potential. The possibility that some may be useful in partial responders to tumor necrosis factor blocking agents or in synergy with the latter is discussed.

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Citations

Jan 12, 2005·Arthritis Research & Therapy·Iain B McInnesJ Alastair Gracie
May 19, 2005·Arthritis Research & Therapy·Paul G Green
Dec 20, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Marina StolinaDebra J Zack
Mar 1, 2006·Rheumatic Diseases Clinics of North America·Christine Savage, E William St Clair
Aug 1, 2008·Arthritis and Rheumatism·Maroun KhouryFlorence Apparailly
Sep 19, 2006·Best Practice & Research. Clinical Rheumatology·Oliver FitzGerald, Iain McInnes
Nov 8, 2015·BMC Musculoskeletal Disorders·Atsuo TanimotoMutsuyoshi Matsushita
Apr 15, 2005·Molecular Immunology·Marco LondeiLuigi Maiuri
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin Pelletier, Denis Girard

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