Targeting death receptors in cancer with Apo2L/TRAIL

Current Opinion in Pharmacology
Sean K Kelley, A Ashkenazi

Abstract

Unlike conventional cancer therapeutics, death receptor ligands trigger tumor cell apoptosis independently of the p53 tumor suppressor gene, which frequently is inactivated in cancer. The death receptor ligand Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) offers promising therapeutic potential based on its ability to induce apoptosis in various cancer cell lines with little toxicity toward normal cells. Moreover, Apo2L/TRAIL displays single-agent activity and cooperates with chemotherapy or radiotherapy in a variety of tumor xenograft mouse models. Thus, Apo2L/TRAIL might be effective against tumors that have acquired resistance to conventional therapy, and could augment the efficacy of current treatment in a wide spectrum of cancers.

Citations

Apr 18, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ronald KoschnyTom M Ganten
Oct 11, 2005·Apoptosis : an International Journal on Programmed Cell Death·S-Y Sun
May 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·Albert F KaboreSpencer B Gibson
Feb 6, 2009·Apoptosis : an International Journal on Programmed Cell Death·Thomas Newsom-DavisHenning Walczak
Apr 8, 2011·Current Treatment Options in Oncology·Andrea Cercek, Leonard Saltz
Jun 27, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zhihong ZhangJinsong Liu
Oct 22, 2005·Nature Reviews. Cancer·Stephen W Fesik
Nov 8, 2008·Nature Reviews. Drug Discovery·Avi Ashkenazi
Oct 20, 2007·Cell Death and Differentiation·C W Chan, F Housseau
Oct 15, 2005·Leukemia·S H Kaufmann, D P Steensma
May 29, 2007·Oncogene·K TakedaM J Smyth
Aug 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ailsa J FrewRicky W Johnstone
Jul 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·Stéphanie SolierYves Pommier
Apr 13, 2012·The Journal of Biological Chemistry·Christopher C ValleyJonathan N Sachs
Mar 18, 2009·The Journal of Biological Chemistry·Subramanian SenthivinayagamBasabi Rana
Jan 27, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shin OkuyamaKen-ichi Sawada
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P LiuP Hou
Oct 29, 2008·Molecular and Cellular Biology·Stéphanie SolierYves Pommier
Oct 3, 2007·Cancer Research·Xiaoping ZhangAria F Olumi
Jun 17, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mary M McCarthyHarriet M Kluger
Apr 8, 2010·Molecular Cancer Therapeutics·Sahdeo PrasadBharat B Aggarwal
Sep 8, 2007·The Journal of Clinical Investigation·Venugopalan CheriyathErnest C Borden
Dec 22, 2011·Journal of Hematology & Oncology·Benjawan WudtiwaiRatana Banjerdpongchai
Dec 31, 2008·PloS One·Michela GarofaloGerolama Condorelli

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