Targeting dementias through cancer kinases inhibition

Alzheimer's & Dementia : Translational Research & Clinical Interventions
Francesca FagianiStefano Govoni

Abstract

The failures in Alzheimer's disease (AD) therapy strongly suggest the importance of reconsidering the research strategies analyzing other mechanisms that may take place in AD as well as, in general, in other neurodegenerative dementias. Taking into account that in AD a variety of defects result in neurotransmitter activity and signaling efficiency imbalance, neuronal cell degeneration and defects in damage/repair systems, aberrant and abortive cell cycle, glial dysfunction, and neuroinflammation, a target may be represented by the intracellular signaling machinery provided by the kinome. In particular, based on the observations of a relationship between cancer and AD, we focused on cancer kinases for targeting neurodegeneration, highlighting the importance of targeting the intracellular pathways at the intersection between cell metabolism control/duplication, the inhibition of which may stop a progression in neurodegeneration.

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Citations

Mar 13, 2021·Frontiers in Cell and Developmental Biology·Elvira Mass, Rebecca Gentek
Jun 25, 2021·Neuropathology and Applied Neurobiology·Thais Rafael GuimarãesAmantha Thathiah

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Methods Mentioned

BETA
nuclear translocation
transgenic
gene knockout

Clinical Trials Mentioned

NCT02167256
NCT01872598
NCT00976118
NCT03402659
NCT03435861
NCT02947893
NCT03757325
NCT00948259
NCT01350362

Software Mentioned

Multivariate Cognitive Endopoint
TU
DIAN

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