Targeting Dendritic Cells in vivo for Cancer Therapy.

Frontiers in Immunology
Irina CaminschiWilliam R Heath

Abstract

Monoclonal antibodies that recognize cell surface molecules have been used deliver antigenic cargo to dendritic cells (DC) for induction of immune responses. The encouraging anti-tumor immunity elicited using this immunization strategy suggests its suitability for clinical trials. This review discusses the complex network of DC, the functional specialization of DC subsets, the immunological outcomes of targeting different DC subsets and their cell surface receptors, and the requirements for the induction of effective anti-tumor CD4 and CD8 T cell responses that can recognize tumor-specific antigens. Finally, we review preclinical experiments and the progress toward targeting human DC in vivo.

Citations

Oct 12, 2012·Pharmaceutical Research·Nitesh K KundaImran Y Saleem
Feb 12, 2014·Current Opinion in Immunology·Kristen J RadfordMireille H Lahoud
Apr 13, 2013·Atherosclerosis·Dimitry A ChistiakovYuri V Bobryshev
Aug 25, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·João ConstantinoBruno M Neves
Dec 10, 2014·European Journal of Immunology·Henrike VeningaJoke M M den Haan
Sep 9, 2015·Scandinavian Journal of Immunology·L H PugholmR Agger
Sep 4, 2015·Scandinavian Journal of Immunology·Lotte Hatting PugholmRalf Agger
Jul 8, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Martine A BoksYvette van Kooyk
Mar 26, 2013·Oncoimmunology·Juan J García-VallejoYvette van Kooyk
Jan 8, 2013·Human Vaccines & Immunotherapeutics·Kristen J Radford, Irina Caminschi
Apr 20, 2014·Frontiers in Immunology·Barbara PlatzerEdda Fiebiger
Jun 7, 2014·Frontiers in Immunology·Kirsteen M TullettKristen J Radford
Jun 21, 2016·Journal de gynécologie, obstétrique et biologie de la reproduction·M NayamaD Vinatier
Nov 20, 2015·Journal of Immunology Research·Cleo Goyvaerts, Karine Breckpot
Mar 1, 2018·Annual Review of Immunology·J Magarian Blander
Oct 2, 2012·Journal of Leukocyte Biology·Annemiek B van Spriel, Esther C de Jong
Oct 31, 2013·Current Opinion in Allergy and Clinical Immunology·Richard WeissJosef Thalhamer
Aug 5, 2015·Pharmacological Reviews·Sébastien AnguilleZwi N Berneman
Sep 6, 2019·Journal for Immunotherapy of Cancer·João CalmeiroBruno Miguel Neves
Nov 6, 2015·Frontiers in Immunology·Fabiola OsorioFermín E González
Jan 22, 2013·Advanced Healthcare Materials·Justine D MinternAngus P R Johnston
Jul 1, 2017·Immunologic Research·João ConstantinoMaria Teresa Cruz
Mar 11, 2020·Frontiers in Immunology·Kyle SaylorChenming Zhang
Jan 9, 2019·Frontiers in Immunology·Chunmei Fu, Aimin Jiang
Sep 7, 2019·Journal of Extracellular Vesicles·Sophie A DusoswaJuan J Garcia-Vallejo
Jul 22, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Julius W KimMaciej S Lesniak
Feb 6, 2019·Frontiers in Immunology·Thiago A PatenteJosé A M Barbuto
Oct 1, 2019·Current Pharmaceutical Design·Alessandra IscaroMunitta Muthana
Mar 1, 2019·Advanced Biosystems·Junyu CaiYaping Li
Aug 15, 2018·Nature Materials·Hua Wang, David J Mooney
Dec 2, 2020·Vaccines·Chunmei FuAimin Jiang
Oct 10, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaehyung ParkKim A Woodrow
Jul 16, 2021·Frontiers in Immunology·Iris A E van der HoornBerber Piet
Nov 20, 2020·Molecular Therapy Oncolytics·Fanny TzelepisJean-Simon Diallo
Nov 2, 2019·Biomacromolecules·Jianxun DingXuesi Chen

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
transgenic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Reviews. Cancer
Karolina Palucka, Jacques Banchereau
Human Vaccines & Immunotherapeutics
Kristen J Radford, Irina Caminschi
© 2021 Meta ULC. All rights reserved